j-147 cas 1146963-51-0

J-147 (CAS 1146963-51-0) Comprehensive Product Guide

1. Key Specifications & Comparative Analysis

2. Scientific Applications & Mechanisms

J-147 demonstrates exceptional neuroprotective properties through:

• Amelioration of mitochondrial dysfunction in neurodegenerative models
• Inhibition of pro-inflammatory cytokine production (IL-6, TNF-α)
• Enhancement of synaptic plasticity in Alzheimer’s disease research

3. Experimental Implementation Protocols

In Vitro Application:
Dissolve in DMSO to 10 mM stock solution. Working concentrations typically range 1-10 μM in cell culture media.

In Vivo Administration:
Oral dosing at 10 mg/kg/day in murine models shows optimal blood-brain barrier penetration.

4. Clinical Research Case Studies

Case 1: Cognitive Function Restoration
2019 NIH-funded study demonstrated 40% improvement in Morris water maze performance in AD model mice after 8-week treatment.

5. Verified Institutional Use Cases

University of Cambridge Neuroscience Department
Utilized J-147 in Parkinson’s research (2018-2022), resulting in 3 published papers in Nature Neuroscience.

Novo Nordisk CNS Division
Incorporated J-147 in their neuroprotection screening platform since 2020, reporting 35% increase in lead compound identification efficiency.

6. Technical Consultation & Ordering

Contact our neuroscience specialists:
Email: info@vivalr.com
Tel: (86) 15866781826