1,10-Phenanthroline (CAS 66-71-7): Technical Guide & Applications
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 1,10-Phenanthroline | Typical Alternatives |
|---|---|---|
| CAS Number | 66-71-7 | Varies by compound |
| Molecular Formula | C12H8N2 | e.g., C10H8N2 (2,2′-Bipyridine) |
| Molecular Weight | 180.21 g/mol | 156.18 g/mol (2,2′-Bipyridine) |
| Melting Point | 114–117°C | 69–73°C (2,2′-Bipyridine) |
| Solubility | 2.69 g/L in water (20°C) | Highly soluble in polar solvents |
| Key Feature | Strong Fe2+ chelation (λmax 510 nm) | Variable metal-binding capacity |
2. Key Applications & Industrial Uses
2.1 Analytical Chemistry
- Iron Quantification: Forms stable orange-red [Fe(phen)3]2+ complex for UV-Vis spectroscopy (detection limit: 0.5–5 ppm).
- Redox Indicator: Transition between colorless (oxidized) and red (reduced) states in titrations.
2.2 Materials Science
- Electroplating Additive: Enhances deposition uniformity in Cu/Fe electroplating baths.
- Coordination Polymers: Serves as bridging ligand in MOF synthesis.
2.3 Pharmaceutical Research
- Enzyme Inhibition: Chelates Zn2+ in metalloproteases (IC50: 10–50 μM).
- Antioxidant Studies: Modulates Fenton reaction kinetics via iron sequestration.
3. Operational Case Studies
Case 1: Water Quality Monitoring
Challenge: Detect trace Fe2+ in groundwater (target: ≤1 ppm).
Solution: 0.1% 1,10-phenanthroline in acetate buffer (pH 5.0).
Result: Linear calibration (R2 = 0.9992) across 0.1–10 ppm range.
Case 2: Electroplating Optimization
Challenge: Reduce dendritic growth in Zn-Ni alloy plating.
Solution: 50 mg/L 1,10-phenanthroline additive.
Result: 40% smoother surface (Ra = 0.8 μm vs. 1.3 μm control).
4. Client Success Stories
Pharmaceutical Research Lab (Shanghai)
Application: MMP-9 inhibition screening
Volume: 5 kg/year (98% purity)
Outcome: Achieved 92% enzyme inhibition at 30 μM concentration.
Advanced Materials Manufacturer (Shenzhen)
Application: Conductive polymer synthesis
Specification: Anhydrous grade (H2O ≤0.1%)
Outcome: Increased conductivity by 3 orders of magnitude vs. bipyridine analogs.
5. Contact for Custom Solutions
Request technical specifications, bulk pricing, or formulation support:
Email: info@vivalr.com
Tel: (86) 15866781826



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