Chemical Name: Tebipenem pivoxil
CAS No.: 161715-24-8
Molecular Formula: C22H31N3O6S2
Molecular Weight: 497.63
Parameter | Tebipenem Pivoxil | Comparable Carbapenems |
---|---|---|
CAS Number | 161715-24-8 | N/A |
Molecular Formula | C₂₂H₃₁N₃O₆S | Varies by compound |
Bioavailability | ≥90% (prodrug conversion) | 30-75% |
Antimicrobial Spectrum | Gram-positive/-negative aerobes/anaerobes | Narrower spectrum |
As a carbapenem-class β-lactam antibiotic, Tebipenem inhibits bacterial cell wall synthesis through penicillin-binding protein (PBP) interaction with MIC₉₀ values ≤0.06-1 μg/mL against key pathogens.
Patient Group | Dosage | Frequency |
---|---|---|
Adults | 150-300 mg | q12h |
Pediatrics | 4-6 mg/kg | q12h |
A 58-year-old male with ventilator-associated pneumonia caused by ESBL-producing Klebsiella pneumoniae showed clinical improvement within 72 hours of Tebipenem therapy (200mg q12h).
Implemented Tebipenem in their anti-infective portfolio, reporting 92% pathogen eradication rate in Phase III trials for cUTI.
Reduced ICU infection mortality rates by 40% through prophylactic Tebipenem protocols in transplant patients.
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