Tetraphenylphosphonium Chloride (CAS 2001-45-8): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Tetraphenylphosphonium chloride (CAS 2001-45-8) is a quaternary phosphonium salt with the chemical formula C24H20ClP. This organophosphorus compound is widely used as:
- Phase-transfer catalyst in organic synthesis
- Ion-pairing agent in analytical chemistry
- Precursor for specialty chemicals
Technical Specifications
| Parameter | Specification |
|---|---|
| Molecular Weight | 374.84 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥98% (HPLC grade available) |
| Solubility | Water: 50 mg/mL, soluble in polar organic solvents |
2. Key Applications & Use Cases
2.1 Organic Synthesis Applications
As a phase-transfer catalyst (PTC), it enables reactions between hydrophilic and hydrophobic reactants in:
- Nucleophilic substitution reactions
- Polymerization processes
- Asymmetric synthesis
2.2 Analytical Chemistry Uses
In HPLC applications, it serves as:
- Ion-pair reagent for acidic analytes
- Mobile phase additive for improved separation
3. Performance Comparison
| Property | TPPCl | TPPBr | TBAHS |
|---|---|---|---|
| Thermal Stability | Up to 250°C | 220°C | 180°C |
| Solubility in H2O | Moderate | High | Excellent |
| Catalytic Efficiency | ★★★★☆ | ★★★☆☆ | ★★☆☆☆ |
4. Industry Application Scenarios
Pharmaceutical Manufacturing
Used in production of:
- Antiviral drug intermediates
- Anticancer compound synthesis
Electronic Materials
Key component for:
- Conductive polymer synthesis
- OLED material preparation
5. Verified Customer Case Studies
Case 1: Specialty Chemical Producer (Germany)
Challenge: Required high-purity PTC for sensitive fluorination reactions
Solution: Implemented our HPLC-grade TPPCl (99.5% purity)
Result: 18% yield improvement with 99% enantiomeric excess
Case 2: Asian Pharmaceutical Company
Challenge: Needed thermally stable catalyst for continuous flow synthesis
Solution: Customized TPPCl formulation with enhanced stability
Result: Achieved 72-hour continuous operation at 200°C
6. Technical Support & Inquiry
Our technical team provides:
- Custom purity formulations (98%-99.9%)
- Bulk quantities (up to 500kg/batch)
- Regulatory documentation support
Contact our experts:
Email: info@vivalr.com
Phone: (86) 15866781826
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