sodium cholate cas 361-09-1

Chemical Name: Sodium Cholate
CAS No.: 361-09-1
Molecular Formula: C28H47N2NaO8S
Molecular weight:594.74
Appearance:white or white powder
Assay: 98%

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Guide to Sodium Cholate (CAS 361-09-1): Applications, Case Studies, and Supplier Insights

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 361-09-1
Chemical Name Sodium Cholate
Molecular Formula C24H39NaO5
Molecular Weight 430.56 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Solubility Freely soluble in water and ethanol
Storage 2-8°C in airtight container

2. Key Applications of Sodium Cholate

2.1 Biochemical Research

– Solubilize membrane proteins & lipids
– Stabilize enzymes in diagnostic kits
– Cell culture additive for nutrient absorption

2.2 Pharmaceutical Manufacturing

– Drug delivery enhancer for hydrophobic APIs
– Enteric coating component
– Cholesterol regulation in formulations

2.3 Industrial Applications

– Emulsifier in cosmetic products
– Food additive (regulated markets)
– Biofuel production catalyst

3. Performance Comparison with Similar Bile Salts

Property Sodium Cholate Sodium Deoxycholate Sodium Taurocholate
Critical Micelle Concentration (CMC) 9-13 mM 2-4 mM 10-15 mM
pH Stability 6.0-8.5 5.0-8.0 6.5-8.5
Protein Stabilization High Medium High
Membrane Disruption Moderate High Low

4. Industry Use Cases

4.1 Drug Formulation Optimization

Enhance bioavailability of poorly soluble drugs through micelle formation at 0.1-0.5% w/v concentrations.

4.2 Diagnostic Kit Production

Maintain reagent stability in lateral flow assays with 0.05-0.2M sodium cholate buffer systems.

4.3 Cosmetic Emulsions

Create stable O/W emulsions in skincare products at 1-3% concentration with pH 6.5-7.5.

5. Verified Customer Case Studies

Case 1: European Pharma Company

Challenge: Improve solubility of antifungal API by 40%
Solution: 0.3% sodium cholate in nanoemulsion
Result: 52% bioavailability increase, FDA approval in 2023

Case 2: US Diagnostic Manufacturer

Challenge: Reduce false positives in rapid tests
Solution: 50mM cholate buffer in conjugate pad
Result: 98.7% specificity achieved, CE marked in Q2 2024

Case 3: Asian Research Institute

Challenge: Extract functional membrane proteins
Solution: 20mM cholate + 150mM NaCl solution
Result: 85% protein recovery rate, 3X faster than previous methods

6. Request a Quote or Technical Support

Contact our bile salt specialists for:
– Bulk pricing (25kg+ quantities available)
– Technical data sheets (SDS, CoA)
– Custom concentration/pre-mixed solutions
Email: info@vivalr.com
Tel: (86) 15866781826

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