Guide to Sodium Cholate (CAS 361-09-1): Applications, Case Studies, and Supplier Insights
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications of Sodium Cholate
- 3. Performance Comparison with Similar Bile Salts
- 4. Industry Use Cases
- 5. Verified Customer Case Studies
- 6. Request a Quote or Technical Support
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 361-09-1 |
| Chemical Name | Sodium Cholate |
| Molecular Formula | C24H39NaO5 |
| Molecular Weight | 430.56 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Solubility | Freely soluble in water and ethanol |
| Storage | 2-8°C in airtight container |
2. Key Applications of Sodium Cholate
2.1 Biochemical Research
– Solubilize membrane proteins & lipids
– Stabilize enzymes in diagnostic kits
– Cell culture additive for nutrient absorption
2.2 Pharmaceutical Manufacturing
– Drug delivery enhancer for hydrophobic APIs
– Enteric coating component
– Cholesterol regulation in formulations
2.3 Industrial Applications
– Emulsifier in cosmetic products
– Food additive (regulated markets)
– Biofuel production catalyst
3. Performance Comparison with Similar Bile Salts
| Property | Sodium Cholate | Sodium Deoxycholate | Sodium Taurocholate |
|---|---|---|---|
| Critical Micelle Concentration (CMC) | 9-13 mM | 2-4 mM | 10-15 mM |
| pH Stability | 6.0-8.5 | 5.0-8.0 | 6.5-8.5 |
| Protein Stabilization | High | Medium | High |
| Membrane Disruption | Moderate | High | Low |
4. Industry Use Cases
4.1 Drug Formulation Optimization
Enhance bioavailability of poorly soluble drugs through micelle formation at 0.1-0.5% w/v concentrations.
4.2 Diagnostic Kit Production
Maintain reagent stability in lateral flow assays with 0.05-0.2M sodium cholate buffer systems.
4.3 Cosmetic Emulsions
Create stable O/W emulsions in skincare products at 1-3% concentration with pH 6.5-7.5.
5. Verified Customer Case Studies
Case 1: European Pharma Company
Challenge: Improve solubility of antifungal API by 40%
Solution: 0.3% sodium cholate in nanoemulsion
Result: 52% bioavailability increase, FDA approval in 2023
Case 2: US Diagnostic Manufacturer
Challenge: Reduce false positives in rapid tests
Solution: 50mM cholate buffer in conjugate pad
Result: 98.7% specificity achieved, CE marked in Q2 2024
Case 3: Asian Research Institute
Challenge: Extract functional membrane proteins
Solution: 20mM cholate + 150mM NaCl solution
Result: 85% protein recovery rate, 3X faster than previous methods
6. Request a Quote or Technical Support
Contact our bile salt specialists for:
– Bulk pricing (25kg+ quantities available)
– Technical data sheets (SDS, CoA)
– Custom concentration/pre-mixed solutions
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