boc-l-valine cas 13734-41-3

Chemical Name:Boc-L-valine
CAS No.: 13734-41-3
Molecular Formula:C10H19NO4
Molecular Weight: 217.26
Appearance:A white to off-white crystalline powder

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Boc-L-Valine (CAS 13734-41-3) Comprehensive User Guide

1. Product Overview & Specifications

Boc-L-Valine (CAS 13734-41-3) is a protected amino acid derivative widely used in peptide synthesis and pharmaceutical research.

Key Parameters

Parameter Specification
CAS Number 13734-41-3
Molecular Formula C10H19NO4
Purity ≥98% (HPLC)
Storage 2-8°C in dry conditions

Competitive Comparison

Feature Boc-L-Valine Fmoc-L-Valine
Acid Stability High Moderate
Deprotection Method TFA Piperidine

2. Key Applications & Usage

Primary Applications

  • Peptide synthesis (SPPS/Fmoc/Boc methodologies)
  • Pharmaceutical intermediates for antiviral drugs
  • Bioconjugation chemistry for antibody-drug conjugates

Handling Guidelines

  • Use anhydrous solvents for dissolution (DCM/DMF recommended)
  • Maintain inert atmosphere for oxygen-sensitive reactions

3. Step-by-Step Usage Examples

Case Study 1: Peptide Chain Elongation

  1. Activate Boc-L-Valine with HOBt/DIC in DMF (1:1:1 molar ratio)
  2. Couple to resin-bound peptide using double coupling protocol
  3. Deprotect with 30% TFA in DCM (2 × 5 min treatments)

4. Customer Success Stories

PharmaTech Solutions (Shanghai)

  • Application: HCV protease inhibitor development
  • Result: Achieved 92% coupling efficiency in solid-phase synthesis

BioConjugate Ltd. (Boston)

  • Application: ADC linker development
  • Result: Improved payload solubility by 40% vs. Fmoc-protected analogs

5. Technical Inquiry & Ordering

Contact our peptide chemistry specialists for technical support:

Why Choose Us?

  • Batch-specific COA with HPLC/LCMS documentation
  • Custom packaging (1g-25kg scale)
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