4-Hexanolide (CAS 695-06-7): Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 4-Hexanolide (γ-Hexalactone) |
| CAS Number | 695-06-7 |
| Molecular Formula | C6H10O2 |
| Molecular Weight | 114.14 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Odor Profile | Sweet herbal, coumarin-like with nutty caramel notes |
| Density (25°C) | 1.020-1.025 g/cm³ |
| Boiling Point | 219°C |
| Flash Point | 98°C (208.4°F) |
| FEMA Number | 2556 |
2. Industrial & Research Applications
2.1 Flavor & Fragrance Industry
- Food Flavors: Enhances cream, vanilla, caramel, and fruit formulations
- Tobacco: Key modifier in premium tobacco blends
- Cosmetics: Base note in lavender and fougère fragrance compositions
2.2 Pharmaceutical Research
- Substrate for paraoxonase-1 (PON1) enzyme studies
- DNA damage response research applications
3. Usage Scenarios & Best Practices
3.1 Formulation Guidelines
| Application | Recommended Concentration |
|---|---|
| Food Flavors | 10-50 ppm |
| Tobacco Blends | 0.1-0.5% w/w |
| Fragrance Compounds | 0.5-2.0% in final formulation |
3.2 Storage Requirements
- Store in sealed containers at 15-25°C
- Protect from direct sunlight and oxidizers
- Shelf life: 24 months in original packaging
4. Client Success Stories
Case Study 1: Flavor Enhancement in Dairy Products
A leading European dairy manufacturer achieved 23% improvement in flavor stability using γ-Hexalactone as a modifier in their premium vanilla ice cream line.
Case Study 2: Tobacco Flavor Optimization
Asian tobacco producer reduced harsh aftertaste by 41% through strategic incorporation of 4-Hexanolide in their menthol cigarette series.
5. Regulatory Compliance & Safety
- FDA 21 CFR 172.515 compliant for food applications
- IFRA standards compliant for cosmetic use
- Restricted in infant formula products (China GB 2760)
- Proper PPE required: gloves, goggles, and vapor respirator
6. Contact for Technical Consultation
For formulation support or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826



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