Chlorodimethyloctadecylsilane (CAS 18643-08-8) Ultimate User Guide 2025
Table of Contents
Product Overview
| Parameter | Specification |
|---|---|
| Chemical Name | Chlorodimethyloctadecylsilane |
| CAS Number | 18643-08-8 |
| Molecular Formula | C20H43ClSi |
| Molecular Weight | 347.10 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | ≥97% (GC) |
| Boiling Point | 180-182°C @ 4mmHg |
| Density | 0.88 g/mL @ 25°C |
| Storage | 2-8°C under inert gas |
Comparative Analysis with Similar Silanes
| Feature | Chlorodimethyloctadecylsilane | Trimethylchlorosilane | Octadecyltrichlorosilane |
|---|---|---|---|
| Carbon Chain Length | C18 | C1 | C18 |
| Reactivity | Moderate | High | Very High |
| Hydrophobicity | Excellent | Poor | Superior |
| Thermal Stability | Up to 250°C | Up to 150°C | Up to 300°C |
| Typical Applications | Surface modification, HPLC columns | Gas chromatography derivatization | Nanoparticle functionalization |
Key Industrial Applications
Surface Modification
Creates water-repellent coatings on glass, metals, and polymers through self-assembled monolayers (SAMs).
Chromatography
Modifies silica gel in HPLC columns for reversed-phase separation of non-polar compounds.
Nanotechnology
Functionalizes quantum dots and nanoparticles to prevent aggregation in biological media.
Rubber Industry
Enhances filler-matrix interaction in silicone rubber composites (2-3% loading typical).
Pharmaceuticals
Surface passivation of drug carriers for controlled release formulations.
Operational Best Practices
Surface Treatment Protocol
- Prepare 2% solution in anhydrous toluene
- Immerse substrate for 12-24 hours at 40°C
- Rinse sequentially with toluene, acetone, and DI water
- Cure at 110°C for 2 hours
Chromatography Column Packing
- Activate silica at 150°C under vacuum for 4 hours
- React with 5% silane solution in dry xylene
- End-cap remaining silanol groups with HMDS
- Slurry pack in 90:10 methanol/water
Client Success Stories
Case 1: Advanced Materials Manufacturer
Client: EuroCoat Technologies GmbH
Challenge: Required durable hydrophobic coating for medical device components
Solution: Developed 0.5μm coating layer with 115° water contact angle
Result: 40% reduction in biofilm formation vs. competitors’ coatings
Case 2: Pharmaceutical Leader
Client: NovoSep Life Sciences
Challenge: Needed stable C18 columns for mRNA vaccine purification
Solution: Custom end-capped columns with pH stability 2-10
Result: 92% recovery rate at production scale
Case 3: Nanotech Startup
Client: QuantumDx Inc.
Challenge: Required stable quantum dots for in vivo imaging
Solution: Surface functionalization protocol with <1% aggregation
Result: Achieved 6-month colloidal stability in PBS
Technical Consultation & Ordering
Our silane experts provide:
- Custom purity grades (97%-99.9%)
- Bulk quantities (25kg drums available)
- Application-specific formulation support
Contact our surface chemistry team:
Email: info@vivalr.com
Tel: (86) 15866781826
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