4-Quinolinecarboxaldehyde (CAS 4363-93-3) Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 4363-93-3 |
| Molecular Formula | C10H7NO |
| Molecular Weight | 157.17 g/mol |
| Appearance | Pale yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 92-95°C |
| Storage Conditions | 2-8°C in inert atmosphere |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates: Critical precursor for antimalarial drugs (e.g., Chloroquine analogs) and kinase inhibitors.
Coordination Chemistry: Chelating agent for transition metal catalysts in asymmetric synthesis.
Material Science: Building block for optoelectronic materials and OLED components.
3. Parameter Comparison with Similar Compounds
| Compound | Reactivity | Thermal Stability | Cost Efficiency |
|---|---|---|---|
| 4-Quinolinecarboxaldehyde | High | Excellent | ★★★☆☆ |
| 2-Pyridinecarboxaldehyde | Moderate | Good | ★★★★☆ |
| Isoquinoline-1-carboxaldehyde | Low | Fair | ★★☆☆☆ |
4. Operational Guidelines & Best Practices
Handling Precautions: Use nitrogen glove box for moisture-sensitive reactions
Purification Methods: Column chromatography (silica gel, eluent: hexane/EA 3:1)
Reaction Optimization: Maintain pH 6-8 in condensation reactions
5. Real-World Application Cases
Case 1: European Pharma Co. achieved 23% yield improvement in antimalarial API synthesis through optimized Buchwald-Hartwig amination.
Case 2: US Research Lab developed novel iridium complexes showing 15% higher luminescence efficiency in OLED prototypes.
Case 3: Asian Chemical Corp. reduced catalyst loading by 40% in cross-coupling reactions through improved ligand design.
6. Technical Inquiry & Purchasing Support
Contact our chemistry experts for:
- Custom synthesis scale-up (mg to kg scale)
- Technical documentation (CoA, MSDS, NMR/HPLC reports)
- Bulk pricing (MOQ 100g)
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