1. Product Overview & Specifications

Chemical Name: 2-Bromopyridine-4-carboxylic acid

CAS No.: 66572-56-3

Molecular Formula: C₆H₄BrNO₂

Molecular Weight: 202.01 g/mol

Parameter Comparison

2. Key Applications

• Pharmaceutical Intermediates: Critical precursor for kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Building block for pyridine-based herbicides.
• Material Science: Ligand in metal-organic frameworks (MOFs).
• Academic Research: Used in heterocyclic compound studies and reaction mechanism analysis.

3. Synthesis Methods

Primary industrial routes:

1. Oxidation of 2-Bromo-4-methylpyridine: Achieves 80-90% yield using KMnO₄ in acidic conditions
2. Halogenation of Isonicotinic Acid: Bromine-mediated reaction under controlled temperatures

4. Industry Use Cases

A. Drug Development

Used in creating third-generation EGFR inhibitors with improved blood-brain barrier penetration.

B. Crop Protection

Key component in next-gen fungicides demonstrating 92% efficacy against Phytophthora infestans.

5. Client Success Stories

Case 1: Beijing Bolade Biotechnology

Challenge: Required high-purity batches for oncology research
Solution: Custom synthesis with HPLC-verified 99.2% purity
Outcome: Accelerated lead compound optimization by 40%

Case 2: Hubei Hongxin Ruiyu Fine Chemical

Challenge: Scalable production for agrochemical clients
Solution: Process optimization achieving 85% yield at 50kg scale
Outcome: Reduced production costs by 22% while meeting ISO standards

6. Contact for Custom Solutions

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