2-Fluoronicotinic Acid: Comprehensive Guide for Industrial Buyers & Researchers
Table of Contents
- 1. Technical Specifications & Comparative Analysis
- 2. Industrial Applications & Functional Advantages
- 3. Operational Guidelines & Safety Protocols
- 4. Application Case Studies
- 5. Verified Client Implementations
- 6. Procurement Strategy & Supplier Evaluation
1. Technical Specifications & Comparative Analysis
| Parameter | 2-Fluoronicotinic Acid | 2-Chloronicotinic Acid | Nicotinic Acid |
|---|---|---|---|
| CAS Number | 393-53-3 | 2942-59-8 | 59-67-6 |
| Molecular Formula | C6H4FNO2 | C6H4ClNO2 | C6H5NO2 |
| Purity Grade | ≥99% (HPLC) | ≥98% | ≥99.5% |
| Melting Point | 158-161°C | 185-188°C | 236°C |
2. Industrial Applications & Functional Advantages
Key Applications:
- Pharmaceutical intermediates for kinase inhibitors
- Agrochemical precursors for systemic herbicides
- Ligand synthesis in coordination chemistry
Performance Advantages:
- Enhanced metabolic stability vs. non-fluorinated analogs
- Improved bioavailability in drug formulations
- Superior halogen bonding capabilities
3. Operational Guidelines & Safety Protocols
Handling Requirements:
- Store in cool (2-8°C), anhydrous environment
- Use nitrogen atmosphere for sensitive reactions
- Compatible with THF, DMF, and dichloromethane
Safety Measures:
- Wear PPE: Nitrile gloves, safety goggles
- Client: Top 10 Global Pharma Company
- Application: FGFR inhibitor intermediate
- Result: 92% yield improvement vs. previous synthesis route
- Client: EU Agrochem Manufacturer
- Application: Systemic action enhancer
- Result: 40% reduction in field application rates
- Usage: Catalytic cross-coupling reactions
- Volume: 150kg/month
- Feedback: “Consistent ≥99.2% purity across 18 batches”
- Usage: Metal-organic framework development
- Volume: 5kg/project
- Feedback: “Critical for achieving precise crystal structures”
- Batch-to-batch consistency (GC-MS certification)
- Regulatory compliance (REACH, TSCA)
- Custom synthesis capabilities
4. Application Case Studies
Case 1: Anticancer Drug Development
Case 2: Next-Gen Herbicide Formulation
5. Verified Client Implementations
Client A: Specialty Chemical Producer (Germany)
Client B: Research Institute (USA)
6. Procurement Strategy & Supplier Evaluation
Supplier Selection Criteria:
Contact Our Experts:
Email: info@vivalr.com
Phone: (86) 15866781826
Request: Custom synthesis | Bulk pricing | SDS


评论
目前还没有评论。