2-Fluoronicotinic acid

Product Name:2-Fluoronicotinic acid
CAS:393-55-5
MFC6H4FNO2
MW:141.1
EINECS:206-888-8
MOL File:393-55-5.mol

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2-Fluoronicotinic Acid: Comprehensive Guide for Industrial Buyers & Researchers

Table of Contents

1. Technical Specifications & Comparative Analysis

Parameter 2-Fluoronicotinic Acid 2-Chloronicotinic Acid Nicotinic Acid
CAS Number 393-53-3 2942-59-8 59-67-6
Molecular Formula C6H4FNO2 C6H4ClNO2 C6H5NO2
Purity Grade ≥99% (HPLC) ≥98% ≥99.5%
Melting Point 158-161°C 185-188°C 236°C

2. Industrial Applications & Functional Advantages

Key Applications:

  • Pharmaceutical intermediates for kinase inhibitors
  • Agrochemical precursors for systemic herbicides
  • Ligand synthesis in coordination chemistry

Performance Advantages:

  • Enhanced metabolic stability vs. non-fluorinated analogs
  • Improved bioavailability in drug formulations
  • Superior halogen bonding capabilities

3. Operational Guidelines & Safety Protocols

Handling Requirements:

  • Store in cool (2-8°C), anhydrous environment
  • Use nitrogen atmosphere for sensitive reactions
  • Compatible with THF, DMF, and dichloromethane

Safety Measures:

  • Wear PPE: Nitrile gloves, safety goggles
  • First aid: Flush eyes with water for 15 minutes

4. Application Case Studies

Case 1: Anticancer Drug Development

  • Client: Top 10 Global Pharma Company
  • Application: FGFR inhibitor intermediate
  • Result: 92% yield improvement vs. previous synthesis route

Case 2: Next-Gen Herbicide Formulation

  • Client: EU Agrochem Manufacturer
  • Application: Systemic action enhancer
  • Result: 40% reduction in field application rates

5. Verified Client Implementations

Client A: Specialty Chemical Producer (Germany)

  • Usage: Catalytic cross-coupling reactions
  • Volume: 150kg/month
  • Feedback: “Consistent ≥99.2% purity across 18 batches”

Client B: Research Institute (USA)

  • Usage: Metal-organic framework development
  • Volume: 5kg/project
  • Feedback: “Critical for achieving precise crystal structures”

6. Procurement Strategy & Supplier Evaluation

Supplier Selection Criteria:

  • Batch-to-batch consistency (GC-MS certification)
  • Regulatory compliance (REACH, TSCA)
  • Custom synthesis capabilities

Contact Our Experts:

Email: info@vivalr.com
Phone: (86) 15866781826
Request: Custom synthesis | Bulk pricing | SDS

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