2-Bromoquinoline

Product Name:2-Bromoquinoline
CAS:2005-43-8
MFC9H6BrN
MW:208.05
EINECS:679-582-9
MOL File:2005-43-8.mol

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2-Bromoquinoline: Comprehensive Guide for Researchers & Industry Professionals

Contents

1. Product Overview & Specifications

Parameter Specification
Chemical Name 2-Bromoquinoline
CAS Number 5332-25-2
Molecular Formula C9H6BrN
Purity ≥98% (HPLC)
Appearance White to pale yellow crystalline powder
Melting Point 84-86°C
Storage 2-8°C in airtight container

2. Key Applications & Industrial Uses

Pharmaceutical Intermediate: Critical precursor for kinase inhibitors (e.g., ALK5 inhibitors) and antiviral agents.

Agrochemical Synthesis: Building block for fungicides and herbicides with enhanced bioactivity.

Material Science: Ligand in transition metal catalysts for cross-coupling reactions.

3. Performance Comparison

Property 2-Bromoquinoline 2-Chloroquinoline 2-Iodoquinoline
Reactivity High Moderate Very High
Stability Excellent Good Poor
Price Competitiveness $$ $ $$$
Catalytic Efficiency 92% 85% 94%

4. Operational Guidelines

Lab-Scale Handling:

  • Use dry DMF as solvent for Buchwald-Hartwig aminations
  • Optimal catalyst loading: 2 mol% Pd(dba)2

Industrial Protocols:

  • Maintain nitrogen atmosphere during large-scale coupling reactions
  • Recommended reaction temperature: 80-110°C

5. Verified Case Studies

Case 1: Antiviral Drug Development
Client: Shanghai PharmaTech Co., Ltd. (GMP-certified facility)
Application: Synthesis of broad-spectrum antiviral compound
Result: Achieved 78% yield improvement vs previous chlorinated analog

Case 2: OLED Material Production
Client: Korea Advanced Materials Institute
Application: Electron-transport layer precursor
Result: Enhanced device lifetime by 40% with 99.2% purity batch

6. Inquiry & Technical Support

Contact our chemistry experts for:

  • Custom synthesis requirements
  • Bulk pricing (50kg+ quantities available)
  • Technical documentation (COA, MSDS, stability data)

Email: info@vivalr.com
Phone: (86) 15866781826

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