5-Chloro-6-hydroxynicotinic Acid: Comprehensive User Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industrial Uses
- 3. Performance Comparison with Analogues
- 4. Operational Guidelines & Best Practices
- 5. Real-World Case Studies
- 6. Technical Support & Inquiry
1. Product Overview & Specifications
| Parameter | 5-Chloro-6-hydroxynicotinic Acid | Similar Compounds |
|---|---|---|
| CAS Number | 374624-70-9 | Varies by derivative |
| Molecular Formula | C6H4ClNO3 | Depends on substitution |
| Purity Grade | ≥98% (HPLC) | Typically 95-99% |
| Solubility | Soluble in DMSO, Methanol | Variable polar solvent compatibility |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Critical precursor for:
- HIV protease inhibitors
- Antibiotic derivatives
- Kinase inhibitor development
Agrochemical Synthesis
Enables production of:
- Chlorinated herbicide components
- Fungicide active ingredients
3. Performance Comparison with Analogues
| Feature | 5-Cl-6-OH Nicotinic Acid | 3-Cl Isomer | 6-OH Nicotinic Acid |
|---|---|---|---|
| Thermal Stability | Up to 220°C | 190°C | 200°C |
| Reaction Yield | 82-88% | 75-80% | 78-83% |
4. Operational Guidelines & Best Practices
Storage Recommendations
- Store at 2-8°C in inert atmosphere
- Moisture-sensitive: use desiccant packs
Reaction Optimization
Recommended conditions for coupling reactions:
- Solvent: Anhydrous DMF
- Temperature: 40-50°C
- Catalyst: HATU/DIPEA system
5. Real-World Case Studies
Case Study 1: Antiviral Drug Synthesis
Client: Indian Pharmaceutical Company
- Application: Darunavir intermediate production
- Result: 22% yield improvement vs previous synthesis route
Case Study 2: Herbicide Development
Client: German Agrochemical Manufacturer
- Application: Chlorinated herbicide precursor
- Result: Achieved 99.2% purity at scale
6. Technical Support & Inquiry
For custom synthesis requirements or technical documents:
Email: info@vivalr.com
Phone: (86) 15866781826
Why Choose Us?
- GMP-compliant production facilities
- Bulk quantities (100kg+) available
- Regulatory support (REACH, DMF filings)


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