5-Chloro-6-hydroxynicotinic Acid

Product Name:5-Chloro-6-hydroxynicotinic Acid
CAS:54127-63-8
MFC6H4ClNO3
MW:173.55
EINECS:
MOL File:54127-63-8.mol

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5-Chloro-6-hydroxynicotinic Acid: Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

Parameter 5-Chloro-6-hydroxynicotinic Acid Similar Compounds
CAS Number 374624-70-9 Varies by derivative
Molecular Formula C6H4ClNO3 Depends on substitution
Purity Grade ≥98% (HPLC) Typically 95-99%
Solubility Soluble in DMSO, Methanol Variable polar solvent compatibility

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Critical precursor for:

  • HIV protease inhibitors
  • Antibiotic derivatives
  • Kinase inhibitor development

Agrochemical Synthesis

Enables production of:

  • Chlorinated herbicide components
  • Fungicide active ingredients

3. Performance Comparison with Analogues

Feature 5-Cl-6-OH Nicotinic Acid 3-Cl Isomer 6-OH Nicotinic Acid
Thermal Stability Up to 220°C 190°C 200°C
Reaction Yield 82-88% 75-80% 78-83%

4. Operational Guidelines & Best Practices

Storage Recommendations

  • Store at 2-8°C in inert atmosphere
  • Moisture-sensitive: use desiccant packs

Reaction Optimization

Recommended conditions for coupling reactions:

  • Solvent: Anhydrous DMF
  • Temperature: 40-50°C
  • Catalyst: HATU/DIPEA system

5. Real-World Case Studies

Case Study 1: Antiviral Drug Synthesis

Client: Indian Pharmaceutical Company

  • Application: Darunavir intermediate production
  • Result: 22% yield improvement vs previous synthesis route

Case Study 2: Herbicide Development

Client: German Agrochemical Manufacturer

  • Application: Chlorinated herbicide precursor
  • Result: Achieved 99.2% purity at scale

6. Technical Support & Inquiry

For custom synthesis requirements or technical documents:

Email: info@vivalr.com
Phone: (86) 15866781826

Why Choose Us?

  • GMP-compliant production facilities
  • Bulk quantities (100kg+) available
  • Regulatory support (REACH, DMF filings)
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