Comprehensive Guide to 4-(Trifluoromethyl)-2-pyrimidinethiol
Table of Contents
- Product Overview & Specifications
- Key Applications & Industrial Uses
- Technical Comparison with Alternatives
- Synthesis & Handling Protocols
- Client Success Stories
- Request Customized Quotes
1. Product Overview & Specifications
| Parameter | Value |
|---|---|
| CAS Number | 34465-01-7 |
| Molecular Formula | C5H3F3N2S |
| Molecular Weight | 180.15 g/mol |
| Appearance | Off-white crystalline powder |
| Purity (HPLC) | >99.5% |
| Storage Conditions | 2-8°C in inert atmosphere |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediate: Critical building block for trifluoromethyl-containing kinase inhibitors in oncology therapeutics.
Agrochemical Synthesis: Core component in next-generation fungicides with enhanced environmental stability.
Material Science: Precursor for functionalized pyrimidine derivatives in OLED manufacturing.
3. Technical Comparison with Alternatives
| Feature | Our Product | Standard Grade | Competitor A |
|---|---|---|---|
| Isomeric Purity | 99.9% | 98.2% | 97.5% |
| Thermal Stability | Stable up to 150°C | Decomposes at 120°C | Degrades at 110°C |
| Solubility (DMSO) | 50 mg/mL | 32 mg/mL | 28 mg/mL |
4. Synthesis & Handling Protocols
Optimal Reaction Conditions:
- Molar ratio 1:1.2 with brominated intermediates
- Catalyzed by Pd(PPh3)4 under nitrogen
- Yield optimization at 65-70°C for 8-12 hours
5. Client Success Stories
Case 1: European Pharma Leader (Confidential) – Achieved 40% yield improvement in JAK2 inhibitor synthesis through our optimized thiol derivatives.
Case 2: APAC CropScience Innovator – Developed novel strobilurin fungicide with 15% broader spectrum activity using our technical-grade material.
6. Request Customized Quotes
Contact our technical team for batch-specific COA or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
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