1. Product Overview & Specifications

Chemical Name: 2-Chloropyrimidine-5-carboxylic Acid
CAS No: 37407-65-7
Molecular Formula: C₅H₃ClN₂O₂
Purity: ≥98% (HPLC)
Appearance: White to off-white crystalline powder

Comparative Analysis

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Widely utilized in synthesizing kinase inhibitors and antiviral agents, particularly in:

• EGFR tyrosine kinase inhibitor development
• HIV protease inhibitor precursors
• Oncology drug candidates

Agrochemical Synthesis

Essential component for:

• Herbicide metabolites
• Fungicidal compound prototyping

3. Operational Guidelines & Best Practices

Storage Protocols

• Store at 2-8°C in sealed containers
• Protect from light and moisture

Reaction Optimization

Recommended conditions for amidation reactions:

• Temperature: 0-5°C (initial stage)
• Coupling Agents: HATU/DIPEA system
• Reaction Time: 4-6 hours

4. Real-World Application Cases

Case Study 1: Antiviral Drug Development

Used as key intermediate in remdesivir analogue synthesis achieving 92% yield in:

• Nucleoside phosphoramidate conjugation
• Viral RNA polymerase inhibition trials

5. Client Success Stories

PharmaTech Solutions (Germany)

Integrated our product into their kinase inhibitor pipeline:

• Reduced synthesis steps from 7 to 4
• Increased batch consistency from ±8% to ±2%
• Achieved 30% cost reduction in lead optimization

AgroChem China Co., Ltd

Utilized in novel fungicide development:

• Enhanced bioactivity by 40% vs previous formulations
• Met EU REACH compliance requirements

6. Technical Consultation & Inquiry

Contact our technical team for:

• Custom synthesis protocols
• Bulk order specifications
• Regulatory support documentation

Email: info@vivalr.com
Phone: (86) 15866781826