2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID

Table of Contents

• Product Overview
• Key Parameters & Comparative Analysis
• Applications in Pharmaceutical & Chemical Industries
• Usage Guidelines & Best Practices
• Industry Case Studies
• Contact for Technical Consultation

2-Fluoro-4-(trifluoromethyl)phenylboronic Acid: Product Overview

CAS Number: 145139-93-7
Molecular Formula: C₇H₅BF₄O₂
Molecular Weight: 223.92 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥97% (HPLC)
Storage: 2-8°C in airtight container, avoid light

Key Parameters & Comparative Analysis

Core Applications

• Pharmaceutical Intermediate: Key building block for EGFR inhibitors and kinase modulators
• Agrochemical Synthesis: Fluorinated active ingredients for next-gen herbicides
• Material Science: Precursor for fluorine-containing OLED materials

Operational Protocols

1. Handle under inert atmosphere (N₂ or Ar) for oxygen-sensitive reactions
2. Recommended catalyst: Pd(PPh₃)₄ (0.5-2 mol%)
3. Optimal reaction temperature: 80-100°C in mixed solvent systems

Documented Case Studies

Case 1: Anticancer Drug Development (2023)

Client: Top 10 Global Pharma Company
Application: Synthesis of PARP inhibitor analogs
Result: Achieved 92% coupling yield in scale-up production

Case 2: Advanced Material Research

Client: Application: Fluoropolymer modification for dielectric materials
Outcome: Enhanced thermal stability by 40% compared to non-fluorinated analogs