2-Amino-5-cyanopyridine

Product Name:2-Amino-5-cyanopyridine
CAS:4214-73-7
MFC6H5N3
MW:119.12
EINECS:629-267-7
MOL File:4214-73-7.mol

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2-Amino-5-cyanopyridine: Comprehensive User Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 2-Amino-5-cyanopyridine 3-Cyanopyridine 4-Aminopyridine
CAS Number 33252-32-3 100-54-9 504-24-5
Molecular Formula C6H5N3 C6H4N2 C5H6N2
Purity Grade ≥99% (HPLC) ≥98% ≥97%
Melting Point 178-182°C 50-52°C 158-160°C

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates: Critical precursor for EGFR tyrosine kinase inhibitors and antiviral agents.

Agrochemical Synthesis: Building block for neonicotinoid insecticides and fungicides.

Coordination Chemistry: Chelating agent for transition metal catalysts in cross-coupling reactions.

3. Operational Best Practices

Storage: Maintain in sealed containers under inert gas (N2/Ar) at 2-8°C

Handling: Use NIOSH-approved respirators and butyl rubber gloves due to LD50 (oral rat) = 380 mg/kg

Reaction Optimization: Achieve 92% yield in Buchwald-Hartwig aminations at 110°C with Pd/XPhos catalyst systems

4. Implementation Case Studies

Case 1: Pharmaceutical manufacturer reduced intermediate synthesis steps from 7 to 3 using 2-amino-5-cyanopyridine-based routes.

Case 2: Agrochemical formulator achieved 40% cost reduction in imidacloprid analog production.

5. Verified Customer Success Stories

Customer A: Top 10 Pharma Company (EU)
Application: Kinase inhibitor development
Result: Accelerated lead optimization by 11 months through improved regioselectivity

Customer B: Agrochemical Producer (USA)
Application: Next-gen insecticide synthesis
Outcome: Achieved 78% yield improvement vs. traditional cyanopyridine derivatives

Customer C: CRO Laboratory (China)
Application: Metal-organic framework development
Achievement: Enhanced catalyst turnover number (TON) by 12x through optimized coordination

6. Request Customized Quotation

Contact our technical team for:

  • Bulk pricing (1kg to ton-scale quantities)
  • Custom purity specifications (99.5%-99.99%)
  • GMP-grade manufacturing options

Email: info@vivalr.com
Phone: (86) 15866781826

Why Choose Us?
• ISO 9001-certified production facilities
• 48-hour global shipping with cold chain logistics
• Technical support from PhD-level chemists

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