3-Bromo-5-methylpyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
3-Bromo-5-methylpyridine (CAS 351385-36-3) is a brominated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key parameters:
| Parameter | Specification |
|---|---|
| Molecular Formula | C6H6BrN |
| Purity | ≥98% (HPLC) |
| Melting Point | 45-48°C |
Comparative Analysis
| Feature | 3-Bromo-5-methylpyridine | 5-Bromo-2-methylpyridine |
|---|---|---|
| Reactivity | High selectivity in Suzuki couplings | Moderate cross-coupling efficiency |
| Pharma Applications | Preferred for kinase inhibitor synthesis | Limited use in API development |
2. Key Applications
Pharmaceutical Intermediates
Critical for synthesizing:
- JAK kinase inhibitors
- BTK inhibitors (e.g., Ibrutinib analogs)
Agrochemical Synthesis
- Herbicide precursors
- Fungicidal compounds
Organic Electronics
- OLED material precursors
- Conductive polymer additives
3. Usage Guidelines
Handling Protocols
- Store at 2-8°C under inert gas
- Use anhydrous conditions for coupling reactions
Synthetic Workflow
- Weigh 1.5g under nitrogen atmosphere
- Dissolve in dry THF (50mL)
- Add Pd(PPh3)4 catalyst (0.1 eq)
4. Industry Case Studies
Pharma API Development
Used in 7-step synthesis of JAK1 inhibitor with 82% overall yield.
OLED Material Production
Key component in blue-emitting layer achieving 18% EQE.
5. Client Success Stories
PharmaCorp (Germany)
- Reduced synthesis steps from 9 to 5
- Increased batch consistency to 99.2%
AgroSolutions Inc (USA)
- Developed novel fungicide with 40% cost reduction
- Achieved EPA approval in 11 months
6. Request Quotation
Contact our technical team for:
- Custom synthesis options
- Bulk pricing (10kg+ quantities)
- Regulatory documentation
Email: info@vivalr.com
Tel: (86) 15866781826


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