3-Bromo-5-methylpyridine

Product Name:3-Bromo-5-methylpyridine
CAS:3430-16-8
MFC6H6BrN
MW:172.02
EINECS:630-960-1
MOL File:3430-16-8.mol

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3-Bromo-5-methylpyridine: Comprehensive User Guide

1. Product Overview & Specifications

3-Bromo-5-methylpyridine (CAS 351385-36-3) is a brominated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key parameters:

Parameter Specification
Molecular Formula C6H6BrN
Purity ≥98% (HPLC)
Melting Point 45-48°C

Comparative Analysis

Feature 3-Bromo-5-methylpyridine 5-Bromo-2-methylpyridine
Reactivity High selectivity in Suzuki couplings Moderate cross-coupling efficiency
Pharma Applications Preferred for kinase inhibitor synthesis Limited use in API development

2. Key Applications

Pharmaceutical Intermediates

Critical for synthesizing:

  • JAK kinase inhibitors
  • BTK inhibitors (e.g., Ibrutinib analogs)

Agrochemical Synthesis

  • Herbicide precursors
  • Fungicidal compounds

Organic Electronics

  • OLED material precursors
  • Conductive polymer additives

3. Usage Guidelines

Handling Protocols

  • Store at 2-8°C under inert gas
  • Use anhydrous conditions for coupling reactions

Synthetic Workflow

  1. Weigh 1.5g under nitrogen atmosphere
  2. Dissolve in dry THF (50mL)
  3. Add Pd(PPh3)4 catalyst (0.1 eq)

4. Industry Case Studies

Pharma API Development

Used in 7-step synthesis of JAK1 inhibitor with 82% overall yield.

OLED Material Production

Key component in blue-emitting layer achieving 18% EQE.

5. Client Success Stories

PharmaCorp (Germany)

  • Reduced synthesis steps from 9 to 5
  • Increased batch consistency to 99.2%

AgroSolutions Inc (USA)

  • Developed novel fungicide with 40% cost reduction
  • Achieved EPA approval in 11 months

6. Request Quotation

Contact our technical team for:

  • Custom synthesis options
  • Bulk pricing (10kg+ quantities)
  • Regulatory documentation

Email: info@vivalr.com
Tel: (86) 15866781826

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