2-Acetyl-5-Chlorothiophene: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Acetyl-5-Chlorothiophene (CAS: 6310-09-4) is an organosulfur compound with the molecular formula C6H5ClOS and a molecular weight of 160.62 g/mol. It is widely utilized in pharmaceutical and agrochemical synthesis due to its reactive acetyl and chlorothiophene groups.
Physical Properties:
| Property | Value |
|---|---|
| Density | 1.312 g/cm³ |
| Melting Point | 46–49°C |
| Boiling Point | 233.3°C at 760 mmHg |
| Flash Point | 108.3°C |
| Vapor Pressure | 0.0562 mmHg at 25°C |
Comparative Analysis:
| Compound | CAS Number | Melting Point | Key Difference |
|---|---|---|---|
| 2-Acetyl-5-Chlorothiophene | 6310-09-4 | 46–49°C | Chlorine substitution at 5th position |
| 2-Acetyl-4-Chlorothiophene | 34730-20-6 | N/A | Chlorine substitution at 4th position |
| 2-Acetyl-5-Bromothiophene | 5370-25-2 | 93–97°C | Bromine substituent instead of chlorine |
2. Key Applications
- Pharmaceutical Intermediates: Used in synthesizing antihistamines and antiviral agents.
- Agrochemicals: Serves as a precursor for herbicides and fungicides.
- Material Science: Modifies polymer properties in specialty coatings.
- Research & Development: Applied in cross-coupling reactions for heterocyclic compound studies.
3. Usage Scenarios
Scenario 1: Antiviral Drug Synthesis
2-Acetyl-5-Chlorothiophene acts as a key intermediate in synthesizing nucleoside analogs, enhancing bioavailability through thiophene ring functionalization.
Scenario 2: Polymer Modification
Incorporated into polythiophene derivatives to improve electrical conductivity in organic semiconductors.
4. Client Case Studies
Case Study 1: PharmaTech Solutions
Challenge: Required a stable intermediate for a novel antihistamine.
Solution: Optimized a 3-step synthesis route using 2-Acetyl-5-Chlorothiophene, achieving 92% purity.
Result: Reduced production costs by 18% and accelerated time-to-market by 6 months.
Case Study 2: AgroChem Innovations
Challenge: Needed a cost-effective fungicide precursor.
Solution: Developed a scalable chlorothiophene derivatization process.
Result: Achieved 30% higher crop protection efficiency compared to traditional formulations.
5. Contact for Inquiries
For technical specifications, bulk pricing, or custom synthesis requests:
Email: info@vivalr.com
Phone: (86) 15866781826


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