5-Ethylpyridine-2,3-dicarboxylic Acid Diethyl ester: Comprehensive User Guide

1. Product Overview & Specifications

5-Ethylpyridine-2,3-dicarboxylic Acid Diethyl Ester (CAS 35224-41-8) is a high-purity ester derivative widely used in pharmaceutical and agrochemical synthesis.

Key Parameters:

2. Key Applications

2.1 Pharmaceutical Intermediates

Used in synthesizing kinase inhibitors and antiviral agents due to its stable pyridine backbone.

2.2 Organic Synthesis

Acts as a ligand precursor in cross-coupling reactions (e.g., Suzuki-Miyaura).

2.3 Agrochemical Research

Critical in developing next-generation herbicides with enhanced bioavailability.

3. Usage Guidelines

3.1 Handling Precautions

• Use nitrogen atmosphere for moisture-sensitive reactions
• Recommended solvent: anhydrous DMF or THF

3.2 Reaction Example

Ester Hydrolysis: Mix 1g compound with 10mL 2M NaOH at 60°C for 4h to yield dicarboxylic acid.

4. Customer Case Studies

4.1 PharmaTech Solutions (Germany)

Challenge: Needed >99% pure intermediate for Phase III clinical trial API.
Solution: Used our ester in Pd-catalyzed amination.
Result: Achieved 99.7% purity, reducing purification costs by 40%.

4.2 AgroChem Ltd (USA)

Challenge: Required stable precursor for field-tested herbicide.
Solution: Implemented our product in solvent-free synthesis.
Result: 92% yield stability at 40°C for 6 months.

5. Contact for Inquiries

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