2-Amino-4-chloropyridine

Product Name:2-Amino-4-chloropyridine
CAS:19798-80-2
MFC5H5ClN2
MW:128.56
EINECS:629-610-0
MOL File:19798-80-2.mol

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2-Amino-4-chloropyridine: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 14432-12-3
Molecular Formula C5H5ClN2
Molecular Weight 128.56 g/mol
Appearance Off-white to light yellow crystalline powder
Purity ≥98% (HPLC)
Melting Point 89-92°C
Solubility Soluble in ethanol, DMSO; slightly soluble in water
Storage 2-8°C in airtight container

2. Applications & Use Cases

Pharmaceutical Intermediates

Key intermediate in synthesizing kinase inhibitors, antiviral agents, and anti-inflammatory drugs.

Agrochemical Development

Used in production of chloropyridine-based herbicides and fungicides with enhanced bioactivity.

Material Science

Building block for coordination polymers and metal-organic frameworks (MOFs).

Organic Synthesis

Versatile reactant for cross-coupling reactions, nucleophilic substitutions, and heterocyclic chemistry.

3. Comparative Analysis

Parameter 2-Amino-4-chloropyridine 2-Amino-3-chloropyridine
Reactivity Higher electrophilicity at C4 Preferential substitution at C2
Thermal Stability Stable up to 150°C Decomposes above 130°C
Synthetic Yield 85-92% (optimized routes) 70-78% (typical)

4. Industry Case Studies

Case 1: Anticancer Drug Development

Client: European Pharma Research Consortium
Challenge: Required high-purity intermediate for Bruton’s tyrosine kinase (BTK) inhibitor synthesis
Solution: Supplied 99.2% pure batch with <0.1% heavy metal content
Outcome: Achieved 94% reaction yield in API synthesis

Case 2: Next-Gen Herbicides

Client: Global Agrochemical Producer
Challenge: Needed scale-up from lab to 500kg production
Solution: Customized synthesis protocol with in-process QC monitoring
Outcome: Maintained 98.5% purity at commercial scale

5. Client Success Stories

University Research Team

Project: Development of luminescent MOFs
Feedback: “Consistent quality enabled reproducible crystal growth results across multiple batches.”

Contract Manufacturing Organization

Project: cGMP production of antiviral intermediates
Feedback: “Met stringent ICH guidelines for residual solvents and genotoxic impurities.”

6. Inquiry & Procurement

Request product samples, technical data sheets, or custom synthesis proposals:

Our experts provide:

  • Batch-specific analytical reports
  • Regulatory support (REACH, TSCA compliant)
  • Custom packaging (1kg to 1000kg)
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