Product Name：2-Amino-4-chloropyridine
CAS：19798-80-2
MFC5H5ClN2
MW：128.56
EINECS：629-610-0
MOL File：19798-80-2.mol
| Parameter | Specification |
|---|---|
| CAS Number | 14432-12-3 |
| Molecular Formula | C5H5ClN2 |
| Molecular Weight | 128.56 g/mol |
| Appearance | Off-white to light yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 89-92°C |
| Solubility | Soluble in ethanol, DMSO; slightly soluble in water |
| Storage | 2-8°C in airtight container |
Key intermediate in synthesizing kinase inhibitors, antiviral agents, and anti-inflammatory drugs.
Used in production of chloropyridine-based herbicides and fungicides with enhanced bioactivity.
Building block for coordination polymers and metal-organic frameworks (MOFs).
Versatile reactant for cross-coupling reactions, nucleophilic substitutions, and heterocyclic chemistry.
| Parameter | 2-Amino-4-chloropyridine | 2-Amino-3-chloropyridine |
|---|---|---|
| Reactivity | Higher electrophilicity at C4 | Preferential substitution at C2 |
| Thermal Stability | Stable up to 150°C | Decomposes above 130°C |
| Synthetic Yield | 85-92% (optimized routes) | 70-78% (typical) |
Client: European Pharma Research Consortium
Challenge: Required high-purity intermediate for Bruton's tyrosine kinase (BTK) inhibitor synthesis
Solution: Supplied 99.2% pure batch with <0.1% heavy metal content
Outcome: Achieved 94% reaction yield in API synthesis
Client: Global Agrochemical Producer
Challenge: Needed scale-up from lab to 500kg production
Solution: Customized synthesis protocol with in-process QC monitoring
Outcome: Maintained 98.5% purity at commercial scale
Project: Development of luminescent MOFs
Feedback: "Consistent quality enabled reproducible crystal growth results across multiple batches."
Project: cGMP production of antiviral intermediates
Feedback: "Met stringent ICH guidelines for residual solvents and genotoxic impurities."
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