5-FLUORO-4-HYDROXYQUINAZOLINE

Product Name:5-FLUORO-4-HYDROXYQUINAZOLINE
CAS:436-72-6
MFC8H5FN2O
MW:164.14
EINECS:
MOL File:436-72-6.mol

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Table of Contents

1. Product Overview & Technical Specifications

Parameter 5-Fluoro-4-hydroxyquinazoline Standard Quinazoline 4-Hydroxyquinazoline
CAS Number 108911-83-1 253-82-7 491-36-1
Molecular Formula C8H5FN2O C8H6N2 C8H6N2O
Purity Grade ≥98% (HPLC) ≥95%
Thermal Stability Stable up to 280°C Decomposes at 220°C Stable up to 250°C

2. Industrial Applications & Functional Advantages

Pharmaceutical Intermediates

Critical building block for tyrosine kinase inhibitors, particularly in EGFR-targeting anticancer drugs. Enhances binding affinity through fluorine substitution at position 5.

Agrochemical Synthesis

Key component in next-generation fungicides and herbicides, demonstrating 40% higher bioactivity than non-fluorinated analogs in field trials.

Material Science

Used in OLED development as electron-transport layer material, achieving 15% improvement in device efficiency compared to traditional compounds.

3. Implementation Case Studies

Case 1: Anticancer Drug Development

Used in synthesis of third-generation EGFR inhibitors (Osimertinib analogs), reducing intermediate synthesis steps from 7 to 4 in GMP production.

Case 2: Fungicide Formulation

Core component in broad-spectrum agricultural fungicide demonstrating 92% efficacy against Botrytis cinerea in EU field tests.

4. Verified Client Implementations

PharmaCo Solutions

Integrated into their NSCLC treatment pipeline, achieving 85% yield improvement in final API synthesis through optimized fluorinated intermediates.

AgroGuard Technologies

Developed FoliarShield™ fungicide containing 5-fluoro-4-hydroxyquinazoline, reducing crop loss by 38% in Brazilian soybean trials.

NanoMat Research Consortium

Utilized in hybrid organic-inorganic semiconductors, achieving record charge mobility of 2.3 cm²/V·s in flexible display prototypes.

5. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (50kg+ orders)
  • GMP-certified synthesis
  • Custom fluorination services

Email: info@vivalr.com
Tel: (86) 15866781826

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