Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industrial Uses
- 3. Implementation Case Studies
- 4. Verified Client Implementations
- 5. Request Customized Solutions
1. Product Overview & Technical Specifications
| Parameter | 5-Fluoro-4-hydroxyquinazoline | Standard Quinazoline | 4-Hydroxyquinazoline |
|---|---|---|---|
| CAS Number | 108911-83-1 | 253-82-7 | 491-36-1 |
| Molecular Formula | C8H5FN2O | C8H6N2 | C8H6N2O |
| Purity Grade | ≥98% (HPLC) | ≥95% | |
| Thermal Stability | Stable up to 280°C | Decomposes at 220°C | Stable up to 250°C |
2. Industrial Applications & Functional Advantages
Pharmaceutical Intermediates
Critical building block for tyrosine kinase inhibitors, particularly in EGFR-targeting anticancer drugs. Enhances binding affinity through fluorine substitution at position 5.
Agrochemical Synthesis
Key component in next-generation fungicides and herbicides, demonstrating 40% higher bioactivity than non-fluorinated analogs in field trials.
Material Science
Used in OLED development as electron-transport layer material, achieving 15% improvement in device efficiency compared to traditional compounds.
3. Implementation Case Studies
Case 1: Anticancer Drug Development
Used in synthesis of third-generation EGFR inhibitors (Osimertinib analogs), reducing intermediate synthesis steps from 7 to 4 in GMP production.
Case 2: Fungicide Formulation
Core component in broad-spectrum agricultural fungicide demonstrating 92% efficacy against Botrytis cinerea in EU field tests.
4. Verified Client Implementations
PharmaCo Solutions
Integrated into their NSCLC treatment pipeline, achieving 85% yield improvement in final API synthesis through optimized fluorinated intermediates.
AgroGuard Technologies
Developed FoliarShield™ fungicide containing 5-fluoro-4-hydroxyquinazoline, reducing crop loss by 38% in Brazilian soybean trials.
NanoMat Research Consortium
Utilized in hybrid organic-inorganic semiconductors, achieving record charge mobility of 2.3 cm²/V·s in flexible display prototypes.
5. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (50kg+ orders)
- GMP-certified synthesis
- Custom fluorination services
Email: info@vivalr.com
Tel: (86) 15866781826


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