3-BROMO-2-FLUORO-6-PICOLINE: Comprehensive Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Use Cases
- 3. Industry-Specific Case Studies
- 4. Client Success Stories
- 5. Technical Comparison & Procurement Guidance
- 6. Contact for Custom Solutions
1. Product Overview & Specifications
| Parameter | 3-Bromo-2-fluoro-6-picoline | Similar Compounds |
|---|---|---|
| CAS Number | 209564-85-4 | 2-Fluoro-6-picoline: 22282-79-9 |
| Molecular Formula | C6H5BrFN | C6H6FN |
| Molecular Weight | 204.02 g/mol | 127.12 g/mol |
| Purity | >98% (HPLC) | >95% |
| Storage | 2-8°C, inert atmosphere | Room temperature |
2. Key Applications & Use Cases
Pharmaceutical Intermediates: Critical in synthesizing kinase inhibitors and CNS drugs due to fluorine/bromine dual functionality.
Agrochemicals: Used in pyridine-based herbicides requiring halogenated side chains for bioactivity.
Material Science: Serves as ligand precursor in cross-coupling reactions (Suzuki, Buchwald-Hartwig).
3. Industry-Specific Case Studies
Case 1: Optimized synthesis of antitumor compound XYZ-123 (Patent WO2023056421) achieved 22% yield improvement using 3-bromo-2-fluoro-6-picoline vs. traditional bromopyridines.
Case 2: Agrochemical producer reduced reaction steps from 5 to 3 in neonicotinoid analog production by leveraging regioselective bromination.
4. Client Success Stories
ABC Pharmaceuticals: Scaled API production to 500kg/month using our GMP-grade material, achieving ICH Q3D compliance for elemental impurities.
DEF Agrosciences: Developed soil-stable insecticide with 40% longer half-life through fluorinated picoline derivatives.
University of GHI: Published 3 Nature Chemistry papers on novel C-F/C-Br activation mechanisms using this compound.
5. Technical Comparison & Procurement Guidance
| Factor | 3-Bromo-2-fluoro-6-picoline | 3-Bromo-6-picoline |
|---|---|---|
| Electrophilicity | High (ortho-F activation) | Moderate |
| Solubility | DCM > THF > EtOAc | THF > DCM |
| Catalog Price | $285/g (R&D) | $180/g |
Procurement Tips: Request batch-specific 19F NMR spectra and residual solvent analysis for sensitive applications.
6. Contact for Custom Solutions
Email: info@vivalr.com
Tel: (86) 15866781826
Request:
- Custom halogenation patterns
- Isotope-labeled versions (D, 13C)
- Bulk pricing (>1kg)


评论
目前还没有评论。