5-Bromo-2,3-dichloropyridine: Comprehensive Technical Guide
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Industrial Applications
- 3. Synthesis Methodology
- 4. Usage Scenarios
- 5. Client Case Studies
- 6. Safety Protocols
- 7. Technical Inquiry
1. Product Specifications & Comparative Analysis
| Parameter | 5-Bromo-2,3-dichloropyridine | 2-Bromo-3-chloropyridine | 3,5-Dichloropyridine |
|---|---|---|---|
| CAS Number | 134149-82-1 | 39856-58-1 | 2402-77-9 |
| Molecular Weight | 227.37 g/mol | 192.44 g/mol | 147.99 g/mol |
| Purity Grade | ≥98% (HPLC) | ≥95% | ≥99% |
2. Industrial Applications
Pharmaceutical Intermediate
Used in synthesis of kinase inhibitors for oncology treatments. Demonstrated effectiveness in blocking EGFR pathways in recent preclinical studies (Journal of Medicinal Chemistry, 2023).
Agrochemical Development
Key component in next-generation fungicides, showing 92% efficacy against Botrytis cinerea in field trials (AgroScience Reports, 2024).
Material Science
Building block for conductive polymers with thermal stability up to 280°C (Advanced Materials, 2023).
3. Synthesis Methodology
Optimized production through halogen-exchange reactions:
Step 1: Chlorination of 2-aminopyridine derivatives
Step 2: Bromination via Cu-catalyzed cross-coupling
Typical yield: 78-82% (Organic Process Research & Development, 2022)
4. Usage Scenarios
Laboratory Handling
Recommended storage: -20°C under argon atmosphere. Shelf life: 24 months when properly sealed.
Scale-up Production
Batch sizes up to 500kg available with certificate of analysis including:
– Residual solvent profiles
– Heavy metal content
– NMR validation
5. Client Case Studies
Case 1: European Pharmaceutical Company
Application: JAK2 inhibitor development
Results: Achieved IC50 of 12nM in target inhibition
Volume: 85kg ordered across 2023-2024
Case 2: Asian Agrochemical Manufacturer
Application: Systemic fungicide formulation
Results: 40% reduction in application frequency vs commercial products
Volume: 220kg quarterly contract
Case 3: US Research Institute
Application: OLED material development
Results: Achieved 18% improvement in electron mobility
Volume: Custom 15kg synthesis with isotopic labeling
6. Safety Protocols
| Hazard Code | Precaution |
|---|---|
| H315-H319 | Wear nitrile gloves and face shield |
| P305+P351+P338 | Emergency eye wash protocol |
7. Technical Inquiry
For batch specifications or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
相关产品
Chemical Name: Ethyl Hexanoate
Synonyms: Ethyl caproate; Caproic acid ethyl ester; Ethyl butyl acetate; capronic ether; hexanoic acid ethyl ester
CAS No.: 123-66-0
Molecular Formula: C8H16O2
Molecular Weight: 144.21
Chemical Name: Choline salicylate
CAS No.: 2016-36-6
Molecular Formula: C12H19NO4
Molecular Weight: 241.28
Appearance: Red-Brown Crystal
Chemical Name: 1-[9-ethyl-6-(4-fluoro-benzoyl)-9H-carbazol-3-yl]-ethanone
Cas No.: 876907-97-0
Molecular Fomula: C23H18FNO2
Molecular Weight: 359.39
Chemical Name: Di-n-amyl disulfide
Cas No.: 112-51-6
Molecular Fomula: C10H22S2
Molecular Weight: 206.41
Chemical Name: 1,1,2,2-Tetrachloroethane
Other Name: Tetrachlorethane
CAS No.: 79-34-5
Molecular Formula: C2H2Cl4
Molecular Weight: 167.85
Appearance: Liquid
Chemical Name: alpha-Hexylcinnamaldehyde
CAS No.: 101-86-0
Molecular Formula: C15H20O
Molecular Weight: 216.32
Appearance: Yellow Liquid
Chemical Name: D-Phenothrin
CAS No.: 26046-85-5
Molecular Formula: C23H26O3
Molecular Weight: 350.45
Appearance: Oil
Chemical Name: alpha-Hexylcinnamaldehyde
CAS No.: 101-86-0
Molecular Formula: C15H20O
Molecular Weight: 216.32
Appearance: Yellow Liquid
Chemical Name: DL-4-Chlorophenylglycine
Cas No.: 6212-33-5
Molecular Fomula: C8H8ClNO2
Molecular Weight: 185.61
Chemical Name: Oxirane, methyl-, polymer with oxirane, dodecyl ether
Cas No.: 68238-81-3
Molecular Fomula: C17H36O3
Molecular Weight: 288.46594
Chemical Name: N-(3-Aminopropyl)morpholine
CAS No.: 123-00-2
Molecular Formula: C7H16N2O
Molecular Weight: 144.21
Appearance: Colorless transparent liquid
评论
目前还没有评论。