2-Chloro-5-fluoronicotinic acid

Product Name:2-Chloro-5-fluoronicotinic acid
CAS:38186-88-8
MFC6H3ClFNO2
MW:175.54
EINECS:
MOL File:38186-88-8.mol

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2-Chloro-5-fluoronicotinic Acid: Technical Guide & Industry Applications

Contents

Product Overview

2-Chloro-5-fluoronicotinic acid (CAS 38186-88-4) is a fluorinated nicotinic acid derivative with molecular formula C₆H₃ClFNO₂. This halogenated heterocyclic compound serves as a critical building block in pharmaceutical intermediates and agrochemical synthesis.

Technical Specifications

Parameter Specification
Molecular Weight 175.55 g/mol
Purity ≥98% (HPLC)
Appearance White to off-white crystalline powder
Melting Point 178-182°C
Storage 2-8°C in dry environment

Comparative Analysis with Similar Compounds

Compound Reactivity Thermal Stability Solubility
2-Chloro-5-fluoronicotinic acid High Excellent Soluble in DMSO, DMF
5-Fluoronicotinic acid Moderate Good Partial solubility
2-Chloronicotinic acid Moderate Fair Limited solubility

Industrial Applications

Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors and antiviral agents, particularly in:

  • EGFR tyrosine kinase inhibitor precursors
  • HIV protease inhibitor intermediates
  • Oncology drug candidates

Agrochemical Development

  • Herbicide metabolites
  • Fungicide active ingredients
  • Plant growth regulator components

Implementation Case Studies

Case 1: Anticancer Drug Development

Client: European Pharma Research Group

Application: Synthesized third-generation EGFR inhibitors showing 89% tumor growth inhibition in preclinical trials

Case 2: Next-Gen Herbicide Formulation

Client: Global Agrochemical Producer

Result: Developed broad-spectrum herbicide with 40% faster action than market benchmarks

Case 3: Organic Electronics Material

Client: Advanced Materials Startup

Outcome: Created electron-transport layers improving OLED efficiency by 22%

Technical Consultation & Ordering

For batch-specific specifications or custom synthesis requirements:

Email: info@vivalr.com

Tel: (86) 15866781826

Request current COA/MSDS documentation or discuss bulk pricing options.

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