2-Chloro-5-fluoronicotinic Acid: Technical Guide & Industry Applications
Contents
- Product Overview
- Technical Specifications & Comparative Analysis
- Industrial Applications
- Case Studies
- Contact for Technical Consultation
Product Overview
2-Chloro-5-fluoronicotinic acid (CAS 38186-88-4) is a fluorinated nicotinic acid derivative with molecular formula C₆H₃ClFNO₂. This halogenated heterocyclic compound serves as a critical building block in pharmaceutical intermediates and agrochemical synthesis.
Technical Specifications
| Parameter | Specification |
|---|---|
| Molecular Weight | 175.55 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Melting Point | 178-182°C |
| Storage | 2-8°C in dry environment |
Comparative Analysis with Similar Compounds
| Compound | Reactivity | Thermal Stability | Solubility |
|---|---|---|---|
| 2-Chloro-5-fluoronicotinic acid | High | Excellent | Soluble in DMSO, DMF |
| 5-Fluoronicotinic acid | Moderate | Good | Partial solubility |
| 2-Chloronicotinic acid | Moderate | Fair | Limited solubility |
Industrial Applications
Pharmaceutical Intermediates
Used in synthesis of kinase inhibitors and antiviral agents, particularly in:
- EGFR tyrosine kinase inhibitor precursors
- HIV protease inhibitor intermediates
- Oncology drug candidates
Agrochemical Development
- Herbicide metabolites
- Fungicide active ingredients
- Plant growth regulator components
Implementation Case Studies
Case 1: Anticancer Drug Development
Client: European Pharma Research Group
Application: Synthesized third-generation EGFR inhibitors showing 89% tumor growth inhibition in preclinical trials
Case 2: Next-Gen Herbicide Formulation
Client: Global Agrochemical Producer
Result: Developed broad-spectrum herbicide with 40% faster action than market benchmarks
Case 3: Organic Electronics Material
Client: Advanced Materials Startup
Outcome: Created electron-transport layers improving OLED efficiency by 22%
Technical Consultation & Ordering
For batch-specific specifications or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Request current COA/MSDS documentation or discuss bulk pricing options.


评论
目前还没有评论。