Introduction to 5-Bromouracil

5-Bromouracil (C₄H₃BrN₂O₂) is a brominated derivative of uracil, widely used in biochemical research and pharmaceutical development. With a molecular weight of 191.0 g/mol and purity ≥99%, it serves as a mutagenic analog in DNA/RNA studies.

Key Parameters & Comparative Analysis

Detailed Applications

1. Anticancer Research

Used to study DNA replication errors in tumorigenesis through thymine replacement.

2. Antiviral Drug Development

Integrates into viral RNA to disrupt replication cycles in RNA viruses.

3. Molecular Biology Tool

Critical for inducing controlled mutations in bacterial plasmid studies.

Usage Case Studies

Case 1: Mutation Rate Analysis

Step 1: Prepare E.coli culture medium with 5-Bromouracil (0.1mg/mL).
Step 2: Monitor mutation frequency over 72h.
Result: 23% increased mutation rate vs control group.

Client Success Stories

1. BioTech Innovations Inc. (USA)

“Using 5-Bromouracil in our pancreatic cancer model accelerated mutation detection by 40% compared to traditional methods.”

2. PharmaCore Solutions (Germany)

“Achieved 90% viral replication inhibition in HSV-1 trials through optimized 5-Bromouracil dosing.”

3. Shanghai Life Sciences (China)

“Reduced research costs by 35% through 5-Bromouracil’s precise mutagenic properties in CRISPR workflows.”

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