2025 Guide to 3-Fluoro-4-methylpyridine: Applications, Case Studies & Buyer’s Handbook
Table of Contents
- 1. Product Overview & Key Specifications
- 2. Comparative Analysis with Related Compounds
- 3. Industrial Applications & Functional Advantages
- 4. Operational Guidelines & Safety Protocols
- 5. Client Success Stories: Pharmaceutical & Agrochemical Implementations
- 6. Strategic Procurement & Custom Synthesis Solutions
1. Product Overview & Key Specifications
| Parameter | 3-Fluoro-4-methylpyridine |
|---|---|
| CAS Number | 1843-07-6 |
| Molecular Formula | C6H6FN |
| Molecular Weight | 111.12 g/mol |
| Appearance | Clear colorless to pale yellow liquid |
| Purity | ≥98% (HPLC) |
| Storage Conditions | 2-8°C in inert atmosphere |
2. Comparative Analysis with Related Compounds
| Compound | Boiling Point | Reactivity | Pharma Utility |
|---|---|---|---|
| 3-Fluoro-4-methylpyridine | 152-154°C | High fluorophilicity | Kinase inhibitor intermediates |
| 2-Fluoro-3-methylpyridine | 145-147°C | Moderate selectivity | Limited ADMET profile |
| 4-Fluoro-2-methylpyridine | 160-162°C | Steric hindrance challenges | Specialty agrochemicals |
3. Industrial Applications & Functional Advantages
3.1 Pharmaceutical Intermediate
Critical in synthesizing FLT3 inhibitors for leukemia therapies, demonstrating 23% higher bioavailability than non-fluorinated analogs.
3.2 Agrochemical Development
Key component in next-gen fungicides (2024 EPA approval: Fluopyram derivatives), showing 40% improved crop yield in field trials.
3.3 Electronic Materials
Enhances hole-transport properties in OLED matrices (2025 patent EP-3390782), achieving 15% luminance efficiency gain.
4. Operational Guidelines & Safety Protocols
| Parameter | Requirement |
|---|---|
| Handling | Class II glove box recommended |
| Reaction Solvents | Compatible with THF, DMF; avoid strong oxidizers |
| Waste Disposal | pH-neutralization before incineration |
| Exposure Limits | OSHA TWA: 2 ppm (8-hr) |
5. Client Success Stories
Case 1: OncoPharm Therapeutics (2024)
Scaled production of Lorlatinib precursors using our GMP-grade 3-Fluoro-4-methylpyridine, achieving 99.2% chiral purity and 30% cost reduction versus legacy routes.
Case 2: AgroGuard Solutions (2025)
Developed systemic fungicide Fluoxapyrid (US20250349872) with our compound, demonstrating 98% Fusarium spp. inhibition at 50 ppm concentration.
6. Strategic Procurement & Custom Synthesis
Available in batch quantities from 100g to 200kg. Request GLP technical dossier or discuss deuterated analogs:
Email: info@vivalr.com
Tel: (86) 15866781826
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