4-Amino-2-chloropyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Amino-2-chloropyridine (CAS 14432-12-3) is a halogenated pyridine derivative widely used in pharmaceutical and agrochemical synthesis. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥99% | ≥98% | ≥97.5% |
| Melting Point | 89-92°C | 87-90°C | 85-88°C |
| Solubility | Soluble in ethanol, DMF | Limited in DMF | Poor in ethanol |
2. Key Applications
Pharmaceutical Intermediate
Critical for synthesizing antiviral agents and kinase inhibitors due to its dual functional groups enabling selective modifications.
Agrochemical Production
Used in neonicotinoid insecticide precursors with 30% higher reaction yield compared to traditional intermediates.
3. Usage Guidelines
Reaction Conditions
- Optimal temperature range: 40-60°C
- pH stability: 6.0-8.0
Safety Protocols
| Parameter | Requirement |
|---|---|
| Storage | 2-8°C in amber glass |
| PPE | Nitrile gloves, vapor respirator |
4. Industry Use Cases
Case 1: Anticancer Drug Synthesis
Used as key building block in PD-1/PD-L1 inhibitors, achieving 92% coupling efficiency in Suzuki-Miyaura reactions.
5. Client Success Stories
Shanghai PharmTech Co., Ltd.
Achieved 40% cost reduction in c-Met inhibitor production through optimized amination processes using our 4-amino-2-chloropyridine.
Nanjing AgroSolutions
Developed next-generation systemic insecticides with 15% improved field efficacy using our high-purity compound.
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