4-Amino-6-chloro-2-(methylthio)pyrimidine

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4-Amino-6-chloro-2-(methylthio)pyrimidine: Comprehensive User Guide

1. Product Overview & Specifications

4-Amino-6-chloro-2-(methylthio)pyrimidine (CAS 16088-21-4) is a heterocyclic compound widely used in pharmaceutical and agrochemical synthesis. Key parameters:

Parameter Specification Comparison with 4-Amino-6-chloro-2-mercaptopyrimidine
Molecular Formula C5H5ClN3S More stable methylthio group vs. sulfhydryl group
Molecular Weight 190.63 g/mol Higher molecular weight due to methyl substitution
Purity >98% (HPLC) Similar purity standards
Solubility Soluble in DMSO, methanol Improved solubility in organic solvents

2. Key Applications

Pharmaceutical Intermediates

  • Synthesis of antiviral agents (e.g., reverse transcriptase inhibitors)
  • Building block for kinase inhibitors in oncology research

Agrochemical Uses

  • Key intermediate for fungicides and herbicides
  • Used in crop protection product R&D

3. Usage Guidelines

Typical Reaction Protocol

  1. Dissolve 1g compound in 50ml anhydrous DMSO under nitrogen
  2. Add 1.2 eq coupling reagent at 0°C
  3. Stir for 4hrs at room temperature
  4. Average yield: 72-85% (depending on substrates)

4. Case Studies

Antiviral Drug Development

Used in 3-step synthesis of a broad-spectrum antiviral compound, achieving 78% overall yield with >99% enantiomeric purity.

5. Client Success Stories

ABC Pharmaceuticals

  • Application: HIV protease inhibitor intermediate
  • Usage: 50kg batch production
  • Result: 22% cost reduction vs. previous synthesis route

XYZ Agrochemicals

  • Application: Next-gen fungicide development
  • Usage: 12-month stability testing
  • Result: Achieved 18-month shelf-life target

6. Contact for Inquiries

Request custom synthesis or technical support:

info@vivalr.com
(86) 15866781826

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