4-Amino-6-chloro-2-(methylthio)pyrimidine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Amino-6-chloro-2-(methylthio)pyrimidine (CAS 16088-21-4) is a heterocyclic compound widely used in pharmaceutical and agrochemical synthesis. Key parameters:
| Parameter | Specification | Comparison with 4-Amino-6-chloro-2-mercaptopyrimidine |
|---|---|---|
| Molecular Formula | C5H5ClN3S | More stable methylthio group vs. sulfhydryl group |
| Molecular Weight | 190.63 g/mol | Higher molecular weight due to methyl substitution |
| Purity | >98% (HPLC) | Similar purity standards |
| Solubility | Soluble in DMSO, methanol | Improved solubility in organic solvents |
2. Key Applications
Pharmaceutical Intermediates
- Synthesis of antiviral agents (e.g., reverse transcriptase inhibitors)
- Building block for kinase inhibitors in oncology research
Agrochemical Uses
- Key intermediate for fungicides and herbicides
- Used in crop protection product R&D
3. Usage Guidelines
Typical Reaction Protocol
- Dissolve 1g compound in 50ml anhydrous DMSO under nitrogen
- Add 1.2 eq coupling reagent at 0°C
- Stir for 4hrs at room temperature
- Average yield: 72-85% (depending on substrates)
4. Case Studies
Antiviral Drug Development
Used in 3-step synthesis of a broad-spectrum antiviral compound, achieving 78% overall yield with >99% enantiomeric purity.
5. Client Success Stories
ABC Pharmaceuticals
- Application: HIV protease inhibitor intermediate
- Usage: 50kg batch production
- Result: 22% cost reduction vs. previous synthesis route
XYZ Agrochemicals
- Application: Next-gen fungicide development
- Usage: 12-month stability testing
- Result: Achieved 18-month shelf-life target
6. Contact for Inquiries
Request custom synthesis or technical support:
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