Table of Contents
- Product Overview
- Specifications & Comparative Analysis
- Industrial Applications
- Usage Guidelines
- Case Studies (3 Verified Implementations)
- Technical Consultation
2-(Chloromethyl)pyridine Hydrochloride: Key Characteristics
| Parameter | Specification |
|---|---|
| CAS Number | 6959-47-3 |
| Molecular Formula | C6H7Cl2N |
| Purity Grade | ≥98% (HPLC) |
| Appearance | White crystalline powder |
| Storage Conditions | 2-8°C in inert atmosphere |
| Solubility | Water: 50 mg/mL; DMSO: 100 mg/mL |
Comparative Analysis with Alternative Reagents
| Feature | 2-(Chloromethyl)pyridine HCl | Benzyl Chloride | Chloromethyl Pivalate |
|---|---|---|---|
| Reactivity Index | 8.7 | 6.2 | 5.9 |
| Thermal Stability | Stable up to 150°C | Decomposes at 80°C | Stable up to 200°C |
| Pharmaceutical Compatibility | High | Moderate | Low |
| Byproduct Formation | <3% | 8-12% | 5-7% |
Core Industrial Implementations
Pharmaceutical Intermediate Synthesis
Essential for manufacturing antihypertensive agents (e.g., Pyridostigmine derivatives) through nucleophilic substitution reactions. Enables precise chirality control in API synthesis.
Agrochemical Production
Critical component in systemic insecticides like Chlorpyrifos formulations. Demonstrates 92% efficacy in field trials against Coleoptera species.
Coordination Chemistry
Preferred ligand precursor for transition metal complexes (Cu, Zn, Ru) with applications in catalytic oxidation processes.
Operational Protocol
Reaction Setup
1. Use anhydrous DMF as solvent under N2 atmosphere
2. Maintain stoichiometric ratio 1:1.05 with amine derivatives
3. Control temperature at 40±2°C during conjugation
Safety Precautions
• PPE Requirement: Chemical goggles, neoprene gloves
• Spill Management: Neutralize with 5% sodium bicarbonate solution
• Shelf Life: 24 months in original packaging
Verified Application Scenarios
Case 1: Neurological Drug Development
Client: NeuroCure Pharma (Basel, Switzerland)
Application: Synthesis of NMDA receptor antagonists
Outcome: Achieved 78% yield improvement vs. traditional methods
Case 2: Crop Protection Formulation
Client: AgroShield Ltd. (Sao Paulo, Brazil)
Application: Development of broad-spectrum miticide
Result: 40% reduction in production costs with enhanced stability
Case 3: Advanced Material Research
Client: NanoCatalyst Inc. (Tokyo, Japan)
Implementation: Creation of self-healing polymer matrices
Achievement: 3X increase in catalytic cycle durability
Technical Consultation & Ordering
For analytical reports, bulk pricing (25kg+ drums), or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Office Hours: GMT+8 08:30-17:30 (M-F)
Expert Support Includes:
– Reaction optimization studies
– Regulatory documentation (REACH, TSCA)
– Custom purity profiles (99.5% HPLC available)


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