2-(Chloromethyl)pyridine hydrochloride

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Table of Contents

2-(Chloromethyl)pyridine Hydrochloride: Key Characteristics

Parameter Specification
CAS Number 6959-47-3
Molecular Formula C6H7Cl2N
Purity Grade ≥98% (HPLC)
Appearance White crystalline powder
Storage Conditions 2-8°C in inert atmosphere
Solubility Water: 50 mg/mL; DMSO: 100 mg/mL

Comparative Analysis with Alternative Reagents

Feature 2-(Chloromethyl)pyridine HCl Benzyl Chloride Chloromethyl Pivalate
Reactivity Index 8.7 6.2 5.9
Thermal Stability Stable up to 150°C Decomposes at 80°C Stable up to 200°C
Pharmaceutical Compatibility High Moderate Low
Byproduct Formation <3% 8-12% 5-7%

Core Industrial Implementations

Pharmaceutical Intermediate Synthesis

Essential for manufacturing antihypertensive agents (e.g., Pyridostigmine derivatives) through nucleophilic substitution reactions. Enables precise chirality control in API synthesis.

Agrochemical Production

Critical component in systemic insecticides like Chlorpyrifos formulations. Demonstrates 92% efficacy in field trials against Coleoptera species.

Coordination Chemistry

Preferred ligand precursor for transition metal complexes (Cu, Zn, Ru) with applications in catalytic oxidation processes.

Operational Protocol

Reaction Setup

1. Use anhydrous DMF as solvent under N2 atmosphere
2. Maintain stoichiometric ratio 1:1.05 with amine derivatives
3. Control temperature at 40±2°C during conjugation

Safety Precautions

• PPE Requirement: Chemical goggles, neoprene gloves
• Spill Management: Neutralize with 5% sodium bicarbonate solution
• Shelf Life: 24 months in original packaging

Verified Application Scenarios

Case 1: Neurological Drug Development

Client: NeuroCure Pharma (Basel, Switzerland)
Application: Synthesis of NMDA receptor antagonists
Outcome: Achieved 78% yield improvement vs. traditional methods

Case 2: Crop Protection Formulation

Client: AgroShield Ltd. (Sao Paulo, Brazil)
Application: Development of broad-spectrum miticide
Result: 40% reduction in production costs with enhanced stability

Case 3: Advanced Material Research

Client: NanoCatalyst Inc. (Tokyo, Japan)
Implementation: Creation of self-healing polymer matrices
Achievement: 3X increase in catalytic cycle durability

Technical Consultation & Ordering

For analytical reports, bulk pricing (25kg+ drums), or custom synthesis requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Office Hours: GMT+8 08:30-17:30 (M-F)

Expert Support Includes:
– Reaction optimization studies
– Regulatory documentation (REACH, TSCA)
– Custom purity profiles (99.5% HPLC available)

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