5-Chloropyrimidin-2-amine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
CAS Number: 22155-21-9
Molecular Formula: C4H4ClN3
Molecular Weight: 129.55 g/mol
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥98% |
| Melting Point | 185-189°C |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
Competitive Comparison
| Feature | 5-Chloropyrimidin-2-amine | 2-Aminopyrimidine | 5-Bromopyrimidin-2-amine |
|---|---|---|---|
| Reactivity | High (Cl group) | Moderate | High (Br group) |
| Cost Efficiency | $$ | $ | $$$ |
| Pharma Applications | ★★★★☆ | ★★★☆☆ | ★★★★☆ |
2. Key Applications & Uses
Pharmaceutical Intermediate
Widely used in synthesizing kinase inhibitors for cancer therapeutics (e.g., EGFR inhibitors).
Agrochemical Development
Key precursor for fungicides and herbicides due to its stable heterocyclic structure.
Material Science
Building block for organic semiconductors and coordination polymers.
3. Usage Scenarios
Case 1: Anticancer Drug Synthesis
Reaction: Suzuki-Miyaura coupling with boronic acids
Yield: 82-88% under Pd catalysis
Case 2: Pesticide Formulation
Process: Nucleophilic substitution with thiols
Efficacy: 95% pest mortality at 50ppm concentration
4. Customer Success Stories
ABC Pharmaceuticals (Germany)
Application: Developed third-generation EGFR inhibitor
Result: Reduced IC50 by 40% compared to previous analogs
AgroGreen Solutions (USA)
Application: Broad-spectrum fungicide
Result: Achieved EPA approval in 14 months
5. Request Custom Synthesis
Contact our technical team for:
- Bulk quantities (1kg-1000kg)
- GMP-grade synthesis
- Custom functionalization
Email: info@vivalr.com
Phone: (86) 15866781826
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