2-Pyrimidinemethanol: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

2-Pyrimidinemethanol (CAS 17281-52-2) is a heterocyclic organic compound with molecular formula C5H6N2O, widely used as a critical intermediate in pharmaceutical synthesis.

Parameter Specification
Molecular Weight 110.11 g/mol
Purity ≥98% (HPLC)
Appearance White to off-white crystalline powder
Storage 2-8°C in airtight container

2. Key Applications & Use Cases

Primary Industrial Uses:

  • Antiviral drug intermediates (e.g., Remdesivir analogs)
  • Kinase inhibitor development for oncology treatments
  • Agrochemical precursors for fungicide formulations

Typical Reaction Pathways:

Reaction Type Application Example
Nucleophilic substitution Synthesis of pyrimidine-based PROTAC molecules
Esterification Prodrug development for improved bioavailability

3. Parameter Comparison (By Supplier)

Supplier Purity Packaging Lead Time Price/kg
Sigma-Aldrich 97% 5g, 25g 4-6 weeks $1,850
TCI Chemicals 98% 1g, 5g 3-5 weeks $1,720
VIVALR 99% 100g-10kg 2 weeks $1,580

4. Industry-Specific Implementation Scenarios

Pharmaceutical Manufacturing:

Process Example: Scale-up synthesis for clinical trial materials involving:

  1. Chloropyrimidine intermediate preparation
  2. Methanolysis under nitrogen atmosphere
  3. Purification via column chromatography

5. Verified Customer Case Studies

Case 1: Oncology Research Institute (Germany)

  • Application: Development of CDK4/6 inhibitors
  • Consumption: 8kg over 18-month research period
  • Result: Successful IND submission for breast cancer therapy

Case 2: Agrochemical Manufacturer (Brazil)

  • Formulation: Broad-spectrum fungicide for soybean crops
  • Batch Size: 200kg production scale
  • Yield Improvement: 12% cost reduction vs previous synthesis route

6. Request Customized Quotation

Contact our technical team for batch-specific COA documentation and volume pricing:

Customization Options:

  • GMP-grade manufacturing available
  • Custom packaging (including argon-sparged containers)
  • Regulatory support documentation
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