METHYL 2,4-DICHLOROPYRIMIDINE-6-CARBOXYLATE

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Methyl 2,4-Dichloropyrimidine-6-Carboxylate: Comprehensive User Guide

1. Product Overview & Specifications

Methyl 2,4-Dichloropyrimidine-6-Carboxylate is a specialized pyrimidine derivative widely used in pharmaceutical and agrochemical research. Key specifications include:

Parameter Details
CAS Number 87600-71-3 (structural analog reference)
Molecular Formula C7H5Cl2N2O2
Molecular Weight 220.03 g/mol
Purity ≥95% (HPLC)

Note: Custom synthesis and purity grades available upon request.

2. Key Applications

This compound serves as a critical intermediate in:

  • Pharmaceutical synthesis (e.g., antiviral and anticancer drug development)
  • Agrochemical production (herbicide and pesticide precursors)
  • Organic electronics (semiconductor material research)
  • Protecting group strategies in nucleoside chemistry

3. Usage Guidelines

Handling & Storage

  • Store at 2–8°C in airtight containers
  • Use under inert gas (N2 or Ar) for moisture-sensitive reactions

Reaction Optimization

  • Typical coupling conditions: 0.1–1.0 eq in DMF/DCM at 0–25°C
  • Compatible with Suzuki-Miyaura and Buchwald-Hartwig cross-couplings

4. Case Studies

Case 1: Antiviral Drug Intermediate

A research team successfully utilized this compound to synthesize a novel non-nucleoside reverse transcriptase inhibitor, achieving 78% yield in the key coupling step.

Case 2: Herbicide Development

Derivatization of the pyrimidine core enabled creation of a herbicidal agent with 90% weed suppression efficacy at 50 ppm concentration.

5. Client Success Stories

Client Application Outcome
Shanghai PharmaTech Oncology candidate synthesis Reduced synthesis steps from 8 to 5
EuroAgro Solutions Next-gen herbicide development Field trial success in 3 countries

6. Request a Quote

For pricing, bulk orders, or technical support:

Custom synthesis and analytical data packages available.

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