2-(Chloromethyl)pyridine

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2-(Chloromethyl)pyridine: Technical Guide for Industrial Applications

1. Product Specifications & Comparative Analysis

Parameter 2-(Chloromethyl)pyridine 5-Chloro-2-(chloromethyl)pyridine
CAS Number 4377-33-7 10177-24-9
Molecular Formula C6H6ClN C6H5Cl2N
Molecular Weight 127.57 g/mol 162.02 g/mol
Storage Form Hydrochloride salt (enhanced stability)

Note: The hydrochloride form is recommended for long-term storage due to the reactive nature of the chloromethyl group.

2. Key Applications in Industrial Chemistry

Critical Roles in Synthesis:

  • Agrochemical Intermediates: Primary precursor for neonicotinoid insecticides (e.g., imidacloprid)
  • Pharmaceutical Building Block: Synthesis of antiviral agents and kinase inhibitors
  • Ligand Development: Coordination chemistry applications in catalysis
  • Surface Modification: Functionalization of polymers and nanomaterials

3. Operational Guidelines & Stability Considerations

Best Practices:

  • Maintain anhydrous conditions during reactions (max H2O < 0.1%)
  • Store at 2-8°C under nitrogen atmosphere
  • Use within 6 months of opening sealed containers
  • QC Recommendation: Implement HPLC analysis (C18 column, 0.1% TFA in mobile phase)

4. Industrial Case Studies

Case 1: Neonicotinoid Production

Client: Leading agrochemical manufacturer (Asia)

  • Annual Consumption: 85 metric tons
  • Process Optimization: Achieved 92% yield in ammoniation step
  • Purity Standard: ≥99.5% (HPLC)

Case 2: Antiviral API Synthesis

Client: European pharmaceutical company

  • Application: Key intermediate in neuraminidase inhibitor production
  • Scale: 2,400 kg/year production
  • Regulatory Compliance: Meets ICH Q7 guidelines

5. Procurement & Custom Synthesis Services

Available Services:

  • Bulk quantities (100kg+ drum orders)
  • Custom salt formulations (hydrochloride, sulfate)
  • Isotope-labeled derivatives (13C, 2H)

Quality Assurance:

Batch-specific COA with:

  • HPLC chromatograms
  • Residual solvent analysis
  • Heavy metal screening

Contact Technical Team:

Email: info@vivalr.com
Tel: (86) 15866781826

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