2-(Chloromethyl)pyridine: Technical Guide for Industrial Applications
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 2-(Chloromethyl)pyridine | 5-Chloro-2-(chloromethyl)pyridine |
|---|---|---|
| CAS Number | 4377-33-7 | 10177-24-9 |
| Molecular Formula | C6H6ClN | C6H5Cl2N |
| Molecular Weight | 127.57 g/mol | 162.02 g/mol |
| Storage Form | Hydrochloride salt (enhanced stability) | |
Note: The hydrochloride form is recommended for long-term storage due to the reactive nature of the chloromethyl group.
2. Key Applications in Industrial Chemistry
Critical Roles in Synthesis:
- Agrochemical Intermediates: Primary precursor for neonicotinoid insecticides (e.g., imidacloprid)
- Pharmaceutical Building Block: Synthesis of antiviral agents and kinase inhibitors
- Ligand Development: Coordination chemistry applications in catalysis
- Surface Modification: Functionalization of polymers and nanomaterials
3. Operational Guidelines & Stability Considerations
Best Practices:
- Maintain anhydrous conditions during reactions (max H2O < 0.1%)
- Store at 2-8°C under nitrogen atmosphere
- Use within 6 months of opening sealed containers
- QC Recommendation: Implement HPLC analysis (C18 column, 0.1% TFA in mobile phase)
4. Industrial Case Studies
Case 1: Neonicotinoid Production
Client: Leading agrochemical manufacturer (Asia)
- Annual Consumption: 85 metric tons
- Process Optimization: Achieved 92% yield in ammoniation step
- Purity Standard: ≥99.5% (HPLC)
Case 2: Antiviral API Synthesis
Client: European pharmaceutical company
- Application: Key intermediate in neuraminidase inhibitor production
- Scale: 2,400 kg/year production
- Regulatory Compliance: Meets ICH Q7 guidelines
5. Procurement & Custom Synthesis Services
Available Services:
- Bulk quantities (100kg+ drum orders)
- Custom salt formulations (hydrochloride, sulfate)
- Isotope-labeled derivatives (13C, 2H)
Quality Assurance:
Batch-specific COA with:
- HPLC chromatograms
- Residual solvent analysis
- Heavy metal screening
Contact Technical Team:
Email: info@vivalr.com
Tel: (86) 15866781826


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