4-FORMYL-1-METHYL-PYRIDINIUM BENZENESULFONATE: Comprehensive Guide for Industrial & Research Applications
Table of Contents
- Product Overview & Specifications
- Key Applications & Industrial Uses
- Technical Comparison with Alternatives
- Operational Guidelines & Safety Protocols
- Industry Case Studies
- Procurement & Customization Options
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 131039-87-1 |
| Molecular Formula | C₁₄H₁₃NO₄S |
| Molecular Weight | 291.32 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Solubility | Soluble in DMSO, DMF; sparingly soluble in water |
2. Key Applications & Industrial Uses
2.1 Pharmaceutical Intermediate
Critical for synthesizing kinase inhibitors and targeted cancer therapies, particularly in:
- EGFR tyrosine kinase inhibitor production
- BTK (Bruton’s tyrosine kinase) inhibitor development
- PARP inhibitor manufacturing
2.2 Organocatalysis
Superior performance in asymmetric catalysis for:
- Chiral amine synthesis
- Enantioselective aldol reactions
- Michael addition reactions
3. Technical Comparison with Alternatives
| Feature | 4-FMPBS | Standard Pyridinium Salts |
|---|---|---|
| Thermal Stability | Stable up to 250°C | Decomposes at 180-200°C |
| Catalytic Efficiency | 85-92% yield in aldol reactions | 70-75% yield |
4. Operational Guidelines & Safety Protocols
4.1 Storage Requirements
- Store at 2-8°C in amber glass containers
- Relative humidity <40%
4.2 Handling Procedures
- Use NIOSH-approved P100 respirators
- Chemical-resistant gloves (Butyl rubber recommended)
5. Industry Case Studies
Case Study 1: Oncology API Manufacturing
Client: Top 10 Global Pharma Company
Challenge: Improve yield in osimertinib intermediate synthesis
Solution: Implemented 4-FMPBS as key catalyst
Results: 22% yield increase with 99.3% enantiomeric excess
Case Study 2: Specialty Chemical Production
Client: EU-based Fine Chemicals Manufacturer
Application: Chiral ligand synthesis for agrochemicals
Outcome: Reduced production costs by 18% through improved catalytic cycles
6. Procurement & Customization Options
Available configurations:
- Research samples (1g-100g)
- Bulk quantities (25kg drums)
- GMP-grade batches
Contact our technical team for formulation optimization:
- Email: info@vivalr.com
- Phone: (86) 15866781826


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