4-FORMYL-1-METHYL-PYRIDINIUM BENZENESULFONATE

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4-FORMYL-1-METHYL-PYRIDINIUM BENZENESULFONATE: Comprehensive Guide for Industrial & Research Applications

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 131039-87-1
Molecular Formula C₁₄H₁₃NO₄S
Molecular Weight 291.32 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Solubility Soluble in DMSO, DMF; sparingly soluble in water

2. Key Applications & Industrial Uses

2.1 Pharmaceutical Intermediate

Critical for synthesizing kinase inhibitors and targeted cancer therapies, particularly in:

  • EGFR tyrosine kinase inhibitor production
  • BTK (Bruton’s tyrosine kinase) inhibitor development
  • PARP inhibitor manufacturing

2.2 Organocatalysis

Superior performance in asymmetric catalysis for:

  • Chiral amine synthesis
  • Enantioselective aldol reactions
  • Michael addition reactions

3. Technical Comparison with Alternatives

Feature 4-FMPBS Standard Pyridinium Salts
Thermal Stability Stable up to 250°C Decomposes at 180-200°C
Catalytic Efficiency 85-92% yield in aldol reactions 70-75% yield

4. Operational Guidelines & Safety Protocols

4.1 Storage Requirements

  • Store at 2-8°C in amber glass containers
  • Relative humidity <40%

4.2 Handling Procedures

  • Use NIOSH-approved P100 respirators
  • Chemical-resistant gloves (Butyl rubber recommended)

5. Industry Case Studies

Case Study 1: Oncology API Manufacturing

Client: Top 10 Global Pharma Company

Challenge: Improve yield in osimertinib intermediate synthesis

Solution: Implemented 4-FMPBS as key catalyst

Results: 22% yield increase with 99.3% enantiomeric excess

Case Study 2: Specialty Chemical Production

Client: EU-based Fine Chemicals Manufacturer

Application: Chiral ligand synthesis for agrochemicals

Outcome: Reduced production costs by 18% through improved catalytic cycles

6. Procurement & Customization Options

Available configurations:

  • Research samples (1g-100g)
  • Bulk quantities (25kg drums)
  • GMP-grade batches

Contact our technical team for formulation optimization:

  • Email: info@vivalr.com
  • Phone: (86) 15866781826
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