5-Bromo-2,4-dichloropyrimidine

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5-Bromo-2,4-dichloropyrimidine: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

CAS Number: 16059-36-6

Molecular Formula: C4BrCl2N2

Molecular Weight: 242.83 g/mol

Parameter Specification
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98%
Melting Point 89-93°C
Storage Conditions 2-8°C in inert atmosphere

2. Key Applications & Industry Use Cases

Pharmaceutical Intermediates

Critical building block for antiviral agents like reverse transcriptase inhibitors. Enables precise bromine-chlorine substitution patterns crucial for drug-target binding.

Agrochemical Synthesis

Used in crop protection chemical development, particularly fungicides requiring halogenated pyrimidine cores for bioactivity.

Material Science

Key precursor for electronic materials requiring halogen-doped aromatic systems in OLED and semiconductor applications.

3. Technical Comparison with Analogues

Compound Reactivity Stability Typical Yield
5-Bromo-2,4-dichloropyrimidine High (Buchwald-Hartwig coupling) Air-sensitive 82-88%
2,4-Dichloropyrimidine Moderate Stable 75-80%
5-Iodo-2,4-dichloropyrimidine Very High Light-sensitive 65-72%

4. Operational Guidelines & Safety Protocols

Handling Procedures

• Always use glove boxes under nitrogen atmosphere for weighing
• Quench reactions with 10% sodium thiosulfate solution

Solubility Data

• DCM: 50 mg/mL
• THF: 32 mg/mL
• Water: <1 mg/mL

5. Client Success Stories

Case 1: Antiviral Drug Development

Client: Top 10 Global Pharma Company
Application: Synthesis of NNRTI candidate (Phase II)
Result: Achieved 92% coupling efficiency vs. 78% with alternative reagents

Case 2: Advanced Material Research

Client: OLED Materials Innovator
Application: Electron transport layer component
Result: Enhanced device lifetime by 40% compared to standard materials

6. Request Customized Solutions

Our technical team provides:

  • Bulk synthesis up to 100kg scale
  • Custom halogenation patterns
  • GMP-grade production

Contact our experts:
Email: info@vivalr.com
Phone: (86) 15866781826

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