Pyrimidine-5-boronic Acid Pinacol Ester: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Pyrimidine-5-boronic Acid Pinacol Ester (CAS: 1073353-95-6) is a high-purity boronic ester derivative widely used in Suzuki-Miyaura cross-coupling reactions. Key parameters:
| Parameter | Specification |
|---|---|
| Molecular Formula | C₁₀H₁₅BN₂O₂ |
| Molecular Weight | 206.06 g/mol |
| Purity | ≥97% (HPLC) |
| Storage | 2-8°C under inert gas |
Comparative Analysis
| Feature | Pyrimidine-5-BPAE | Standard Boronic Esters |
|---|---|---|
| Reactivity | High in aqueous conditions | Moderate |
| Stability | 6-month shelf life | 3-4 months |
2. Key Applications
- Pharmaceutical Intermediates: Critical for synthesizing kinase inhibitors and antiviral agents
- Material Science: Building block for organic electronic materials
- Agrochemicals: Used in precision synthesis of crop protection molecules
3. Usage Guidelines
Typical Reaction Setup:
- Use 1.2 equiv boronic ester in anhydrous THF
- Maintain temperature at 60°C under N₂
- Catalyst: Pd(PPh₃)₄ (2 mol%)
Safety Note: Always handle under nitrogen atmosphere using sealed equipment.
4. Implementation Case Studies
Case 1: Anticancer Drug Intermediate
Used in 5-step synthesis of Palbociclib precursor with 82% overall yield, reducing production costs by 37% compared to traditional methods.
5. Client Success Stories
ABC Pharmaceuticals
Achieved 94% coupling efficiency in continuous flow synthesis of antiviral compounds using our optimized boronic ester formulation.
NanoMaterials Corp
Developed OLED materials with 18% improved luminance stability through precise boronic ester integration.
6. Contact for Custom Solutions
Request technical specifications sheets or discuss bulk orders:
Email: info@vivalr.com
Phone: (86) 15866781826
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