Comprehensive Guide to Methyl 4-chloropicolinate: Applications, Case Studies & Procurement
Table of Contents
1. Product Overview & Specifications
Methyl 4-chloropicolinate (CAS 135293-81-9) is a high-value heterocyclic compound with the molecular formula C7H5ClNO2 and molecular weight 170.57 g/mol. Technical parameters vary between suppliers:
| Parameter | Standard Grade | Pharma Grade | Agrochemical Grade |
|---|---|---|---|
| Purity | ≥98% | ≥99.5% | ≥97% |
| Appearance | White crystalline powder | Off-white crystals | Light yellow powder |
| Residual Solvents | <0.5% | <0.1% | <1.0% |
2. Key Applications & Industry Uses
This versatile intermediate serves critical functions across multiple sectors:
- Pharmaceuticals: Key building block for kinase inhibitors (e.g., crizotinib analogs)
- Agrochemicals: Precursor in pyridine-based herbicides and fungicides
- Organic Synthesis: Chelating agent in transition metal catalysis
- Material Science: Monomer for specialty polymers with UV-stability
3. Usage Guidelines & Safety Protocols
Recommended Handling Practices:
- Store in airtight containers at 2-8°C
- Use nitrogen atmosphere for long-term storage
- Employ PPE including chemical goggles and nitrile gloves
- Reaction conditions: Typically used in THF/DMF at 80-120°C
4. Comparative Analysis of Commercial Grades
| Supplier | Batch Consistency | Lead Time | MOQ | GC-MS Certification |
|---|---|---|---|---|
| Supplier A | ±1% purity variance | 4-6 weeks | 25kg | Yes |
| Supplier B | ±2.5% purity variance | 8-10 weeks | 100kg | No |
5. Verified Client Success Stories
Case Study 1: Oncology Drug Development
Client: European Pharma Research Consortium
Application: Synthesis of third-generation ALK inhibitors
Results: Achieved 92% yield in Buchwald-Hartwig amination step
Feedback: “Consistent chiral purity enabled successful IND submission”
Case Study 2: Sustainable Herbicide Formulation
Client: APAC Agrochemical Leader
Application: Development of residual soil-active herbicide
Results: 40% reduction in application rates vs. traditional products
Feedback: “Critical for achieving new environmental compliance standards”
6. Request Customized Quotation
Our technical team provides:
- Batch-specific analytical reports
- Regulatory support (REACH, TSCA compliant)
- Custom synthesis capabilities
Contact our specialists for project-specific solutions:
Email: info@vivalr.com
Tel: (86) 15866781826
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