2,6-Dimethyl-3-hydroxypyridine (CAS 100356-99-6) is a high-purity heterocyclic compound widely used in pharmaceuticals, agrochemicals, and coordination chemistry. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥99.5% | 98.8% | 97.2% |
| Solubility | Water: 85 g/L Ethanol: Fully miscible |
72 g/L | 68 g/L |
| Thermal Stability | Stable up to 250°C | 220°C | 200°C |
Critical for synthesizing antihypertensive drugs and CNS modulators due to its unique chelating properties.
Enhances fungicide stability in crop protection formulations under extreme pH conditions.
Preferred ligand for transition metal catalysts in asymmetric synthesis (e.g., Ru-based catalysts).
Store in airtight containers at 15-25°C with ≤60% humidity. Shelf life: 36 months.
For Suzuki couplings: Use 1:1.2 molar ratio with boronic acids at 80-100°C under inert atmosphere.
A European pharma company achieved 22% yield improvement in Olodaterol intermediate synthesis by replacing 2,4-lutidine with our compound.
Stabilized a triazole fungicide against hydrolysis at pH 9.2 in Brazilian sugarcane plantations.
Challenge: Reduce metal catalyst loading in Parkinson's drug synthesis
Solution: Implemented 2,6-dimethyl-3-hydroxypyridine as co-ligand
Result: 40% reduction in Pd usage while maintaining 99% ee
Challenge: Premature degradation of imidacloprid analogs
Solution: Added 0.5% w/w of our compound
Result: Extended field efficacy from 14 to 28 days
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