| Parameter | 3-Chloro-4-cyanopyridine | 2-Chloro-4-cyanopyridine | 4-Cyanopyridine |
|---|---|---|---|
| CAS Number | 943401-93-2 | 33252-27-2 | 1452-42-6 |
| Molecular Formula | C6H3ClN2 | C6H3ClN2 | C6H4N2 |
| Purity Grade | ≥99% (HPLC) | ≥98% | ≥97% |
| Reactivity Profile | Electrophilic substitution at 2-position | Nucleophilic substitution at 3-position | Limited functionalization |
Critical precursor for kinase inhibitors (EGFR, ALK) with enhanced bioavailability compared to non-cyano analogs.
Key building block for systemic insecticides targeting nicotinic acetylcholine receptors (nAChRs).
Coordination ligand in transition metal complexes for OLED electron transport layers (ETLs).
| Parameter | Specification |
|---|---|
| Storage Conditions | 2-8°C in inert atmosphere (Ar/N2) |
| Handling PPE | Chemically resistant gloves + Full-face respirator |
| Decontamination | 0.5M NaOH solution for equipment cleaning |
European CDMO achieved 83% yield improvement in osimertinib intermediate synthesis through optimized cyano-chloro substitution patterns.
Japanese agrochemical manufacturer developed soil-stable insecticide with 40% longer residual activity versus previous generation products.
Challenge: Needed >99.5% enantiomeric purity for third-generation TKI development
Solution: Customized recrystallization protocol development
Outcome: Achieved 99.7% purity with 30% reduction in solvent usage
Challenge: Required batch-to-batch consistency for OLED deposition processes
Solution: Implemented advanced purification train with inline NIR monitoring
Outcome: Reduced metal impurity levels to <5ppm with 98% yield consistency
Contact our technical specialists for:
- Custom synthesis scale-up protocols
- Regulatory documentation support
- Application-specific purity optimization
Email: info@vivalr.com
Phone: (86) 15866781826
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This is William, CEO of fousi chemical Chemical Co., Ltd.
Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.
