Ethyl 4-Chloro-2-(Methylthio)pyrimidine-5-carboxylate: Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| CAS Number | 5909-24-0 / 2134-36-3* | N/A | N/A |
| Molecular Formula | C8H9ClN2O2S | Similar structure | Different substituents |
| Storage | -20°C (1 month under N2) -80°C (6 months) |
Room temperature | -20°C (no N2) |
| Purity | >98% (HPLC/LCMS verified) | >95% | Unspecified |
*Structural analogs with identical core applications
2. Applications in Life Sciences
Key Research Areas:
- Pharmaceutical intermediates for kinase inhibitors
- Building block in PROTAC® development
- Enzyme activity modulation studies
- High-throughput screening libraries
Mechanistic Advantages:
- Enhanced bioavailability compared to non-ester analogs
- Selective reactivity at C4 position for derivatization
- Optimal lipophilicity (LogP 2.4-4.3) for membrane penetration
3. Usage Guidelines & Case Studies
Recommended Workflow:
- Thaw at 4°C under inert atmosphere
- Use anhydrous solvents for reactions
- Monitor reactions via LCMS (expected MW: 228.68)
Case Example:
Anticancer Lead Optimization: Used as core structure in a 2024 Nature-published study to develop selective CDK inhibitors. Achieved IC50 of 18nM through strategic modifications at the 2-methylthio position.
4. Client Success Stories
Case 1: Top 10 Pharma Company
- Application: PROTAC® degrader development
- Results: 40% improvement in target degradation efficiency vs. commercial analogs
- Scale: 50kg batch production with >99.5% purity
Case 2: University Research Team
- Application: Fluorescent probe development
- Results: Enabled real-time tracking of pyrimidine metabolism in Cell (2023)
- Customization: Isotope-labeled version provided
5. Contact for Custom Solutions
| Service | Lead Time | Contact |
|---|---|---|
| Bulk Orders (>1kg) | 4-6 weeks | info@vivalr.com |
| Custom Derivatives | 8-12 weeks | (86) 15866781826 |
Request SDS or COA: Email Documentation Team
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